Presence of Ascites at Presentation is Associated With Absence of Long-Term Response Amongst Patients With Budd-Chiari Syndrome When Treated With Medical Therapy Alone: A Single Centre Real-Life Experience.

Autor: Agrawal D; Department of Gastroenterology, Seth GSMC and KEM Hospital, Mumbai 400 012, India., Gupta D; Department of Gastroenterology, Seth GSMC and KEM Hospital, Mumbai 400 012, India., Nathani R; Department of Gastroenterology, Seth GSMC and KEM Hospital, Mumbai 400 012, India., Dhore P; Department of Gastroenterology, Seth GSMC and KEM Hospital, Mumbai 400 012, India., Meshram M; Department of Gastroenterology, Seth GSMC and KEM Hospital, Mumbai 400 012, India., Bhatia SJ; Department of Gastroenterology, Seth GSMC and KEM Hospital, Mumbai 400 012, India., Shukla A; Department of Gastroenterology, Seth GSMC and KEM Hospital, Mumbai 400 012, India.
Jazyk: angličtina
Zdroj: Journal of clinical and experimental hepatology [J Clin Exp Hepatol] 2022 May-Jun; Vol. 12 (3), pp. 861-870. Date of Electronic Publication: 2021 Nov 03.
DOI: 10.1016/j.jceh.2021.10.148
Abstrakt: Background: There is lack of data on long-term outcomes of patients with Budd-Chairi Syndrome (BCS) treated with medical therapy including anticoagulation alone.
Methods: Consecutive patients (N = 138, mean [standard deviation, SD] age 29.3 [12.9] years; 66 men) with BCS, treated with medical therapy alone including anticoagulation, with minimum follow-up of 12 months were included. Initial response was classified as complete (CR), partial (PR) or nonresponse (NR) and on follow-up as loss of response (LoR) or maintenance of response (MoR). The association of baseline, clinical and biochemical parameters with different responses was evaluated.
Results: Seventy-six patients (55.1%) had CR, 26 (18.8%) had PR and 36 (26.1%) had NR. None with PR or NR had CR later. At a median follow-up of 40 (range 12-174) months, LoR was more common in PR group than in CR group (12 [46.2%] vs 18 [23.7%], P  = 0.03). LoR was associated with presence of ascites (odds ratio [OR] 1.5; 95% confidence interval [CI] 0.06-0.71), gastrointestinal bleed (OR 1.33; 95% CI 0.09-0.82) or jaundice (OR 1.01; 95% CI 0.11-0.97) at baseline and duration of follow-up (OR 0.018; 95% CI 1.006-1.030). Mortality was higher in NR (28 [77.8%]) compared with CR (15 [19.7%], P  = 0.001) and PR (8 [30.8%], P  = 0.001). On binary logistic regression analysis, presence of ascites at baseline was associated with LoR (OR 0.303 [0.098-0.931]).
Conclusion: Patients with initial CR have better survival than nonresponders. One-third had LoR on follow-up. The presence of ascites at baseline is associated with LoR.
(© 2021 Indian National Association for Study of the Liver. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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