Medicines use before and after comprehensive medicines review among residents of long-term care facilities: a retrospective cohort study.

Autor: Sluggett JK; University of South Australia, UniSA Allied Health and Human Performance, GPO Box 2471, Adelaide, South Australia, Australia. janet.sluggett@unisa.edu.au.; Registry of Senior Australians, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia. janet.sluggett@unisa.edu.au.; Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia. janet.sluggett@unisa.edu.au., Caughey GE; University of South Australia, UniSA Allied Health and Human Performance, GPO Box 2471, Adelaide, South Australia, Australia.; Registry of Senior Australians, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia., Air T; Registry of Senior Australians, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia., Moldovan M; Registry of Senior Australians, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.; Biometry Hub, Faculty of Sciences, Engineering and Technology, The University of Adelaide, Waite Campus, Urrbrae, South Australia, Australia., Lang C; Registry of Senior Australians, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia., Martin G; Australian Association of Consultant Pharmacy, Australian Capital Territory, Fyshwick, Australia., Carter SR; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Jackson S; School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS, Australia., Stafford AC; Curtin Medical School, Faculty of Health Sciences, Curtin University, Perth, WA, Australia., Wesselingh SL; Registry of Senior Australians, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia., Inacio MC; University of South Australia, UniSA Allied Health and Human Performance, GPO Box 2471, Adelaide, South Australia, Australia.; Registry of Senior Australians, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Jazyk: angličtina
Zdroj: BMC geriatrics [BMC Geriatr] 2022 Jun 08; Vol. 22 (1), pp. 493. Date of Electronic Publication: 2022 Jun 08.
DOI: 10.1186/s12877-022-03187-0
Abstrakt: Background: Residential Medication Management Review (RMMR) is a subsidized comprehensive medicines review program for individuals in Australian residential aged care facilities (RACFs). This study examined weekly trends in medicines use in the four months before and after an RMMR and among a comparison group of residents who did not receive an RMMR.
Methods: This retrospective cohort study included individuals aged 65 to 105 years who first entered permanent care between 1/1/2012 and 31/12/2016 in South Australia, Victoria, or New South Wales, and were taking at least one medicine. Individuals with an RMMR within 12 months of RACF entry were classified into one of three groups: (i) RMMR within 0 to 3 months, (ii) 3 to 6 months, or (iii) within 6 to 12 months of RACF entry. Individuals without RMMRs were included in the comparison group. Weekly trends in the number of defined daily doses per 1000 days were determined in the four months before and after the RMMR (or assigned index date in the comparison group) for 14 medicine classes.
Results: 113909 individuals from 1979 RACFs were included, of whom 55021 received an RMMR. Across all three periods examined, decreased use of statins and proton pump inhibitors was observed post-RMMR in comparison to those without RMMRs. Decreases in calcium channel blockers, benzodiazepines/zopiclone, and antidepressants were observed following RMMR provision in the 3-6 and 6-12 months after RACF entry. Negligible changes in antipsychotic use were also observed following an RMMR in the 6-12 months after RACF entry by comparison to those without RMMRs. No changes in use of opioids, ACE inhibitors/sartans, beta blockers, loop diuretics, oral anticoagulants, or medicines for osteoporosis, diabetes or the cognitive symptoms of dementia were observed post-RMMR.
Conclusions: For six of the 14 medicine classes investigated, modest changes in weekly trends in use were observed after the provision of an RMMR in the 6-12 months after RACF entry compared to those without RMMRs. Findings suggest that activities such as medicines reconciliation may be prioritized when an RMMR is provided on RACF entry, with deprescribing more likely after an RMMR the longer a resident has been in the RACF.
(© 2022. The Author(s).)
Databáze: MEDLINE
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