Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats.

Autor: Cellat M; Department of Physiology, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, Hatay, Türkiye., İşler CT; Department of Surgery, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, Hatay, Türkiye., Kutlu T; Department of Pathology, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, Hatay, Türkiye., Kuzu M; Department of Nutrition and Dietetics, Faculty of Health Sciences, Karabuk University, Karabuk, Türkiye., Etyemez M; Department of Physiology, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, Hatay, Türkiye., Alakuş H; Department of Surgery, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, Hatay, Türkiye., Güvenç M; Department of Physiology, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, Hatay, Türkiye.
Jazyk: angličtina
Zdroj: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2022 Sep; Vol. 36 (9), pp. e23140. Date of Electronic Publication: 2022 Jun 08.
DOI: 10.1002/jbt.23140
Abstrakt: Rheumatoid arthritis (RA) is a systemic chronic disease characterized by inflammation and synovitis. More effective treatment methods with less side effects need to be developed. In this context, current study investigated the therapeutic effects of safranal in a model of complete Freund's adjuvant (CFA)-induced RA. The control group was given 1 ml of saline orally starting from the 8th day, and 0.2 ml of CFA was given to the RA, RA + Safranal and RA + Methotrexate (MTX) groups on the 0th day of the experiment. Starting from the 8th day of the experiment, 1 ml of saline was given to the RA group, safranal was given at 200 mg/kg of body weight to the RA + MTX group, and 3 mg/kg of MTX to the RA + MTX group twice a week. The results showed that weight gain decreased in the RA group compared to the control group while arthritis index score, thymus index, and planter temperature were found to be increased. Additionally, a deterioration in blood parameters, an increase in alanine aminotransferase, aspartate aminotransferase, urea, creatinine, C-reactive protein, and malondialdehyde levels, and a decrease in reduced glutathione levels and glutathione peroxidase and catalase (CAT) activities were seen while tumor necrosis factor-α, interleukin-6 (IL-6), cyclooxygenase-2, nuclear factor kappa B levels were found to be increased. However, the safranal had a regulatory effect on all the values, except IL-6 and CAT, and blood parameters. Moreover, histopathological examination revealed that safranal reduced inflammatory cell infiltration and edema.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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