Evaluation of the Association of Single Nucleotide Polymorphism rs2229238 in Interleukin 6 Receptor Alpha (IL6RA) Gene With the Risk of Preeclampsia.

Autor:	Sivaraj N; Research and Development, Great Eastern Medical School and Hospital, Srikakulam, IND.; Biochemistry and Bioinformatics, Gandhi Institute of Technology and Management (Deemed To Be University), Visakhapatnam, IND., K VR; Biochemistry and Bioinformatics, Gandhi Institute of Technology and Management (Deemed To Be University), Visakhapatnam, IND., Suvvari TK; Medicine and Surgery, Dr. Nandamuri Taraka Rama Rao (NTR) University of Health Sciences, Vijayawada, IND., Prasad S; Obstetrics and Gynaecology, Great Eastern Medical School and Hospital, Srikakulam, IND., Sri Harsha B; General Medicine, Great Eastern Medical School and Hospital, Srikakulam, IND., Majji V; Central Research Laboratory, Great Eastern Medical School and Hospital, Srikakulam, IND., Vegi PK; Biochemistry, Great Eastern Medical School and Hospital, Srikakulam, IND., Bunga PK; Research and Development, Great Eastern Medical School and Hospital, Srikakulam, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 May 06; Vol. 14 (5), pp. e24788. Date of Electronic Publication: 2022 May 06 (Print Publication: 2022).
DOI:	10.7759/cureus.24788
Abstrakt:	Introduction Many studies have gone into single nucleotide polymorphisms (SNPs) in inflammatory-associated genes and preeclampsia risk; still, the findings are inconclusive. The current study aims to evaluate the association of SNP rs2229238 in the interleukin 6 receptor alpha (IL6RA) gene with the risk of preeclampsia. Methodology An observational case-control study was conducted and 216 patients were included in this study. Of the patients, 104 were normotensive subjects and 112 were subjects with preeclampsia. Genotyping for SNP rs2229238 was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results The genotype allocation of the SNP 2229238 C/A polymorphism was not different in preeclampsia subjects (CC: 42%; CA: 42%; AA: 16%) and normotensive pregnant women (CC: 37%; CA: 48%; AA: 15%) (p-value = 0.73). The frequency of the A allele was 34% in preeclampsia subjects and 31% in normotensive pregnancies. There was no significant variation seen in the allele frequencies among cases and the control population. Conclusion Our study reported that there is no significant relation between preeclampsia and IL6RA SNP rs2229238. Also, there is no significance in the allele frequencies among both cases and control groups. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Sivaraj et al.)
Databáze:	MEDLINE
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