Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study.

Autor: Auchtung TA; Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA. tauchtung2@unl.edu.; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA. tauchtung2@unl.edu., Stewart CJ; Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Smith DP; Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA., Triplett EW; Microbiology and Cell Science Department, Institute for Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA., Agardh D; Department of Clinical Sciences, Lund University Clinical Research Center, Skåne University Hospital, Malmö, Sweden., Hagopian WA; Pacific Northwest Research Institute, Seattle, WA, USA., Ziegler AG; Institute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany.; Forschergruppe Diabetes, Technische Universität München, Klinikum Rechts der Isar, Munich, Germany.; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, Munich, Germany., Rewers MJ; Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO, USA., She JX; Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.; Jinfiniti Precision Medicine, Inc, Augusta, GA, USA., Toppari J; Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.; Department of Pediatrics, Turku University Hospital, Turku, Finland., Lernmark Å; Department of Clinical Sciences, Lund University/CRC, Skane University Hospital, Malmö, Sweden., Akolkar B; National Institute of Diabetes & Digestive & Kidney Diseases, Bethesda, MD, USA., Krischer JP; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Vehik K; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Auchtung JM; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA.; Nebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE, USA., Ajami NJ; Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.; Program for Innovative Microbiome and Translational Research, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Petrosino JF; Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA. jpetrosi@bcm.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Jun 07; Vol. 13 (1), pp. 3151. Date of Electronic Publication: 2022 Jun 07.
DOI: 10.1038/s41467-022-30686-w
Abstrakt: Fungal infections are a major health problem that often begin in the gastrointestinal tract. Gut microbe interactions in early childhood are critical for proper immune responses, yet there is little known about the development of the fungal population from infancy into childhood. Here, as part of the TEDDY (The Environmental Determinants of Diabetes in the Young) study, we examine stool samples of 888 children from 3 to 48 months and find considerable differences between fungi and bacteria. The metagenomic relative abundance of fungi was extremely low but increased while weaning from milk and formula. Overall fungal diversity remained constant over time, in contrast with the increase in bacterial diversity. Fungal profiles had high temporal variation, but there was less variation from month-to-month in an individual than among different children of the same age. Fungal composition varied with geography, diet, and the use of probiotics. Multiple Candida spp. were at higher relative abundance in children than adults, while Malassezia and certain food-associated fungi were lower in children. There were only subtle fungal differences associated with the subset of children that developed islet autoimmunity or type 1 diabetes. Having proper fungal exposures may be crucial for children to establish appropriate responses to fungi and limit the risk of infection: the data here suggests those gastrointestinal exposures are limited and variable.
(© 2022. The Author(s).)
Databáze: MEDLINE
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