The pks island: a bacterial Swiss army knife? Colibactin: beyond DNA damage and cancer.

Autor: Chagneau CV; IRSD, INSERM, Université de Toulouse, INRAE, ENVT, UPS, Toulouse, France; CHU Toulouse, Hôpital Purpan, Service de Bactériologie-Hygiène, Toulouse, France., Payros D; IRSD, INSERM, Université de Toulouse, INRAE, ENVT, UPS, Toulouse, France; Toxalim, Research center in Food Toxicology, Université de Toulouse, INRAE, ENVT, INP- PURPAN, UPS, Toulouse, France., Tang-Fichaux M; IRSD, INSERM, Université de Toulouse, INRAE, ENVT, UPS, Toulouse, France., Auvray F; IRSD, INSERM, Université de Toulouse, INRAE, ENVT, UPS, Toulouse, France., Nougayrède JP; IRSD, INSERM, Université de Toulouse, INRAE, ENVT, UPS, Toulouse, France., Oswald E; IRSD, INSERM, Université de Toulouse, INRAE, ENVT, UPS, Toulouse, France; CHU Toulouse, Hôpital Purpan, Service de Bactériologie-Hygiène, Toulouse, France. Electronic address: eric.oswald@inserm.fr.
Jazyk: angličtina
Zdroj: Trends in microbiology [Trends Microbiol] 2022 Dec; Vol. 30 (12), pp. 1146-1159. Date of Electronic Publication: 2022 Jun 05.
DOI: 10.1016/j.tim.2022.05.010
Abstrakt: The structure and mode of action of colibactin with its potential involvement in cancer have been extensively studied but little is known about the intrinsic function of the biosynthetic gene cluster, coding for colibactin, as a bacterial genotoxin. Paradoxically, this pathogenicity island is also found in commensal and probiotic strains of Escherichia coli and in bacterial species colonizing olive trees and the digestive tract of bees. In this review, we summarize the available literature to address the following key questions. What does this genomic island really encode? What explains the extensive dissemination of this genetically mobile element? What do we really know about the biosynthetic and secretory pathways of colibactin? What is its inherent target/function?
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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