Killer immunoglobulin-like receptor and cancer.

Autor:	Gómez-Luque JM; Hospital Universitario Materno Infantil Virgen de las Nieves, Granada, Spain., Urrutia-Maldonado E; Hospital Universitario Materno Infantil Virgen de las Nieves, Granada, Spain., Rueda PM; Instituto de Investigación Biosanitaria de Granada, Granada, Spain., Abril-Molina A; Hospital Universitario Materno Infantil Virgen de las Nieves, Granada, Spain., Ocete-Hita E; Hospital Universitario Materno Infantil Virgen de las Nieves, Granada, Spain; Instituto de Investigación Biosanitaria de Granada, Granada, Spain; Universidad de Granada, Granada, Spain. Electronic address: estherocete@ugr.es.
Jazyk:	angličtina
Zdroj:	Anales de pediatria [An Pediatr (Engl Ed)] 2022 May; Vol. 96 (5), pp. 410-415. Date of Electronic Publication: 2022 Jun 04.
DOI:	10.1016/j.anpede.2022.04.002
Abstrakt:	Introduction: Natural killer (NK) cells play an important role in defense against tumor cells. The development and function of NK cells is governed by a dynamic balance between inhibition and activation of cell surface receptors, including KIR receptors. Patients and Method: A case-control study is carried out that compares a group of 46 children diagnosed with malignant diseases, the control group is made up of 82 healthy children. KIRs genes, haplotypes and ligands were determined and compared between groups. Results: There are no differences in KIRs genes, KIRs haplotypes or in KIRs gene ligands between groups. However, when KIRS and ligands were jointly studied, k2DS1_C2 was significantly higher in the group of cancer children (p=0.016). Conclusions: Our results do not provide evidence of an association between pediatric cancer disease with genotypes and groups of genes KIRs. The k2DS1_C2 genotype could predispose to susceptibility to malignant processes in children. (Copyright © 2022. Published by Elsevier España, S.L.U.)
Databáze:	MEDLINE
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