Plastic particles in medicine: A systematic review of exposure and effects to human health.

Autor: Gopinath PM; Centre for Nanobiotechnology, Vellore Institute of Technology (VIT), Tamil Nadu, Vellore, 632 014, India., Parvathi VD; Department of Biomedical Sciences, Faculty of Biomedical Sciences, Technology and Research, SRIHER: Sri Ramachandra Institute of Higher Education and Research, Sri Ramachandra University, Chennai 600116, Tamil Nadu, India., Yoghalakshmi N; Department of Biomedical Sciences, Faculty of Biomedical Sciences, Technology and Research, SRIHER: Sri Ramachandra Institute of Higher Education and Research, Sri Ramachandra University, Chennai 600116, Tamil Nadu, India., Kumar SM; Department of Biomedical Sciences, Faculty of Biomedical Sciences, Technology and Research, SRIHER: Sri Ramachandra Institute of Higher Education and Research, Sri Ramachandra University, Chennai 600116, Tamil Nadu, India., Athulya PA; Centre for Nanobiotechnology, Vellore Institute of Technology (VIT), Tamil Nadu, Vellore, 632 014, India., Mukherjee A; Centre for Nanobiotechnology, Vellore Institute of Technology (VIT), Tamil Nadu, Vellore, 632 014, India., Chandrasekaran N; Centre for Nanobiotechnology, Vellore Institute of Technology (VIT), Tamil Nadu, Vellore, 632 014, India. Electronic address: nchandrasekaran@vit.ac.in.
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2022 Sep; Vol. 303 (Pt 3), pp. 135227. Date of Electronic Publication: 2022 Jun 04.
DOI: 10.1016/j.chemosphere.2022.135227
Abstrakt: Single-use plastics (SUPs) have become an essential constituent of our daily life. It is being exploited in numerous pharmaceutical and healthcare applications. Despite their advantages and widespread use in the pharma and medical sectors, the potential clinical problems of plastics, especially the release of micro-nanoplastics (MNPs) and additives from medical plastics (e.g. bags, containers, and administrative sets) and sorption of drugs remain understudied. Certainly, the MNPs are multifaceted stressors that cause detrimental effects to the ecosystem and human health. The origin and persistence of MNPs in pharmaceutical products, their administration to humans, endurance and possible health implication, translocation, and excretion have not been reviewed in detail. The prime focus of this article is to conduct a systematic review on the leaching of MNPs and additives from pharmaceutical containers/administrative sets and their interaction with the pharmaceutical constituents. This review also explores the primary and secondary routes of MNPs entry from healthcare plastic products and their potential health hazards to humans. Furthermore, the fate of plastic waste generated in hospitals, their disposal, and associated MNPs release to the environment, along with preventive, and alternative measures are discussed herein.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: