Effects of Sugammadex and Neostigmine on Post-operative Nausea and Vomiting in ENT Surgery.

Autor:	Mat NISN; Department of Anesthesiology and Intensive Care, Hospital Duchess of Kent, Sandakan, Malaysia., Yeoh CN; Department of Anesthesiology & Intensive Care, Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia., Maaya M; Department of Anesthesiology & Intensive Care, Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia., Zain JM; Department of Anesthesiology & Intensive Care, Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia., Ooi JSM; Department of Anesthesiology & Intensive Care, Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2022 May 20; Vol. 9, pp. 905131. Date of Electronic Publication: 2022 May 20 (Print Publication: 2022).
DOI:	10.3389/fmed.2022.905131
Abstrakt:	We aim to compare the effects of sugammadex on postoperative nausea and vomiting (PONV) with those of neostigmine-atropine mixture. A total of 136 American Society of Anesthesiology (ASA) I or II patients, aged 18 to 65 years who underwent ear, nose, and throat (ENT) surgery under general anesthesia, were recruited in this prospective, randomized, double-blind study to receive either sugammadex 2 mg/kg or neostigmine 2.5 mg with atropine 1 mg for reversal of neuromuscular blockade. PONV scores and the need for the rescue of anti-emetic were assessed upon arrival in the post-anesthesia recovery unit and at 1-, 6-, 12-, and 24-h post-reversal. The incidence of PONV was significantly lower in patients who received sugammadex (3%) compared to patients who received neostigmine-atropine mixture (20%) at 6 h postoperative ( p = 0.013). The incidence of PONV was comparable at other time intervals. None of the sugammadex recipients require rescue antiemetic whereas two patients from the neostigmine-atropine group required rescue antiemetic at 1 and 6 h post-reversal, respectively. The need for the rescue antiemetic was not statistically significant. We concluded that reversal of neuromuscular blockade with sugammadex showed lower incidence of PONV compared to neostigmine-atropine combination in the first 6 h post-reversal. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Mat, Yeoh, Maaya, Zain and Ooi.)
Databáze:	MEDLINE
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