Neurosurgical management of Tourette syndrome: A literature review and analysis of a case series treated with deep brain stimulation.

Autor:	Tomskiy AA; Department of Functional Neurosurgery, Burdenko National Medical Research Center of Neurosurgery, Moscow, Russian Federation. Electronic address: atomski@nsi.ru., Poddubskaya AA; Department of Functional Neurosurgery, Burdenko National Medical Research Center of Neurosurgery, Moscow, Russian Federation; Psychiatry Research Group, Burdenko National Medical Research Center of Neurosurgery, Moscow, Russian Federation., Gamaleya AA; Department of Functional Neurosurgery, Burdenko National Medical Research Center of Neurosurgery, Moscow, Russian Federation., Zaitsev OS; Psychiatry Research Group, Burdenko National Medical Research Center of Neurosurgery, Moscow, Russian Federation.
Jazyk:	angličtina
Zdroj:	Progress in brain research [Prog Brain Res] 2022; Vol. 272 (1), pp. 41-72. Date of Electronic Publication: 2022 May 18.
DOI:	10.1016/bs.pbr.2022.03.005
Abstrakt:	Tourette syndrome (TS) is a heterogeneous disorder, which clinical presentation includes both multiple motor and vocal tics and commonly associated psychiatric conditions (obsessive-compulsive disorder, attention deficit hyperactivity disorder, depression, anxiety, etc.). Treatment options primarily consist of non-pharmacological interventions (habit reversal training, relaxation techniques, cognitive behavioral therapy, and social rehabilitation) and pharmacotherapy. In case of the intractable forms, neurosurgical treatment may be considered, primarily deep brain stimulation (DBS). DBS appear to be effective in medically intractable TS patients, although, the preferential brain target is still not defined. The majority of studies describe small number of cases and the issues of appropriate patient selection and ethics remain to be clarified. In this article, we review the main points in management of TS, discuss possible indications and contraindications for neurosurgical treatment, and analyze our experience of DBS in a case series of refractory TS patients with the focus on target selection and individual outcomes. (Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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