Naked mole-rat and Damaraland mole-rat exhibit lower respiration in mitochondria, cellular and organismal levels.

Autor: Yap KN; Department of Biological Sciences, Auburn University, Auburn, AL 36849, United States of America; Department of Biology, Norwegian University of Science and Technology, Trondheim 7491, Norway., Wong HS; Calico Life Sciences LLC, South San Francisco, CA 94080, United States of America., Ramanathan C; College of Health Sciences, University of Memphis, Memphis, TN 38152, United States of America., Rodriguez-Wagner CA; Department of Biological Science, University of Memphis, Memphis, TN 38152, United States of America., Roberts MD; School of Kinesiology, Auburn University, Auburn, AL 36849, United States of America., Freeman DA; Department of Biological Science, University of Memphis, Memphis, TN 38152, United States of America., Buffenstein R; Calico Life Sciences LLC, South San Francisco, CA 94080, United States of America. Electronic address: rbuffen@calicolabs.com., Zhang Y; College of Health Sciences, University of Memphis, Memphis, TN 38152, United States of America. Electronic address: yzhang24@memphis.edu.
Jazyk: angličtina
Zdroj: Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2022 Oct 01; Vol. 1863 (7), pp. 148582. Date of Electronic Publication: 2022 Jun 03.
DOI: 10.1016/j.bbabio.2022.148582
Abstrakt: Naked mole-rats (NMR) and Damaraland mole-rats (DMR) exhibit extraordinary longevity for their body size, high tolerance to hypoxia and oxidative stress and high reproductive output; these collectively defy the concept that life-history traits should be negatively correlated. However, when life-history traits share similar underlying physiological mechanisms, these may be positively associated with each other. We propose that one such potential common mechanism might be the bioenergetic properties of mole-rats. Here, we aim to characterize the bioenergetic properties of two African mole-rats. We adopted a top-down perspective measuring the bioenergetic properties at the organismal, cellular, and molecular level in both species and the biological significance of these properties were compared with the same measures in Siberian hamsters and C57BL/6 mice, chosen for their similar body size to the mole-rat species. We found mole-rats shared several bioenergetic properties that differed from their comparison species, including low basal metabolic rates, a high dependence on glycolysis rather than on oxidative phosphorylation for ATP production, and low proton conductance across the mitochondrial inner membrane. These shared mole-rat features could be a result of evolutionary adaptation to tolerating variable oxygen atmospheres, in particular hypoxia, and may in turn be one of the molecular mechanisms underlying their extremely long lifespans.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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