Alterations in the volume of thalamic nuclei in patients with schizophrenia and persistent auditory hallucinations.

Autor:	Perez-Rando M; Institute of Biotechnology and Biomedicine (BIOTECMED), Universitat de València, Burjassot, Spain; Spanish National Network for Research in Mental Health, (CIBERSAM), Madrid, Spain; Institute of Research of the Clinic Hospital from Valencia (INCLIVA), Valencia, Spain. Electronic address: marta.perez-rando@uv.es., Elvira UKA; Institute of Biotechnology and Biomedicine (BIOTECMED), Universitat de València, Burjassot, Spain; Institutes of Biomedical Technologies and Neuroscience, University of La Laguna, San Cristóbal de La Laguna, Spain., García-Martí G; Spanish National Network for Research in Mental Health, (CIBERSAM), Madrid, Spain; Quironsalud Hospital, Valencia, Spain., Gadea M; Spanish National Network for Research in Mental Health, (CIBERSAM), Madrid, Spain; Institute of Research of the Clinic Hospital from Valencia (INCLIVA), Valencia, Spain; Department of Psychobiology, Faculty of Psychology, Universitat de València, Valencia, Spain., Aguilar EJ; Spanish National Network for Research in Mental Health, (CIBERSAM), Madrid, Spain; Psychiatry Unit, Faculty of Medicine, Universitat de València, Valencia, Spain., Escarti MJ; Spanish National Network for Research in Mental Health, (CIBERSAM), Madrid, Spain., Ahulló-Fuster MA; Department of Radiology, Rehabilitation and Physiotherapy. Faculty of Nursing, Physiotherapy and Podiatry. Universidad Complutense de Madrid, Spain., Grasa E; Spanish National Network for Research in Mental Health, (CIBERSAM), Madrid, Spain; Servicio de Psiquiatría. Instituto de Investigación Biomédica Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau. Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain., Corripio I; Spanish National Network for Research in Mental Health, (CIBERSAM), Madrid, Spain; Servicio de Psiquiatría. Instituto de Investigación Biomédica Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau. Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain., Sanjuan J; Spanish National Network for Research in Mental Health, (CIBERSAM), Madrid, Spain; Quironsalud Hospital, Valencia, Spain., Nacher J; Institute of Biotechnology and Biomedicine (BIOTECMED), Universitat de València, Burjassot, Spain; Spanish National Network for Research in Mental Health, (CIBERSAM), Madrid, Spain; Institute of Research of the Clinic Hospital from Valencia (INCLIVA), Valencia, Spain. Electronic address: nacher@uv.es.
Jazyk:	angličtina
Zdroj:	NeuroImage. Clinical [Neuroimage Clin] 2022; Vol. 35, pp. 103070. Date of Electronic Publication: 2022 Jun 01.
DOI:	10.1016/j.nicl.2022.103070
Abstrakt:	The thalamus is a subcortical structure formed by different nuclei that relay information to the neocortex. Several reports have already described alterations of this structure in patients of schizophrenia that experience auditory hallucinations. However, to date no study has addressed whether the volumes of specific thalamic nuclei are altered in chronic patients experiencing persistent auditory hallucinations. We have processed structural MRI images using Freesurfer, and have segmented them into 25 nuclei using the probabilistic atlas developed by Iglesias and collaborators (Iglesias et al., 2018). To homogenize the sample, we have matched patients of schizophrenia, with and without persistent auditory hallucinations, with control subjects, considering sex, age and their estimated intracranial volume. This rendered a group number of 41 patients experiencing persistent auditory hallucinations, 35 patients without auditory hallucinations, and 55 healthy controls. In addition, we have also correlated the volume of the altered thalamic nuclei with the total score of the PSYRATS, a clinical scale used to evaluate the positive symptoms of this disorder. We have found alterations in the volume of 8 thalamic nuclei in both cohorts of patients with schizophrenia: The medial and lateral geniculate nuclei, the anterior, inferior, and lateral pulvinar nuclei, the lateral complex and the lateral and medial mediodorsal nuclei. We have also found some significant correlations between the volume of these nuclei in patients experiencing auditory hallucinations, and the total score of the PSYRATS scale. Altogether our results indicate that volumetric alterations of thalamic nuclei involved in audition may be related to persistent auditory hallucinations in chronic schizophrenia patients, whereas alterations in nuclei related to association cortices are evident in all patients. Future studies should explore whether the structural alterations are cause or consequence of these positive symptoms and whether they are already present in first episodes of psychosis. (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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