Loss of speech and functional impairment in Alzheimer's disease-related primary progressive aphasia: predictive factors of decline.

Autor: Mazzeo S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Polito C; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Lassi M; The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy; Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy., Bagnoli S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy., Mattei M; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy., Padiglioni S; Regional Referral Centre for Relational Criticalities, Tuscany Region, Italy; Unit Clinic of Organizations, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy., Berti V; Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, Florence, Italy; Nuclear Medicine Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Lombardi G; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Giacomucci G; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy., De Cristofaro MT; Nuclear Medicine Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Passeri A; Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, Florence, Italy., Ferrari C; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Mazzoni A; The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy; Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy., Sorbi S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Bessi V; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy. Electronic address: valentina.bessi@unifi.it.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2022 Sep; Vol. 117, pp. 59-70. Date of Electronic Publication: 2022 May 13.
DOI: 10.1016/j.neurobiolaging.2022.05.002
Abstrakt: We aimed to identify features associated with different disease trajectories in Alzheimer's disease (AD)-related primary progressive aphasia (PPA). We considered 23 patients diagnosed with AD-related PPA. All patients underwent neuropsychological evaluation, 18 F-Fluorodeoxyglucose-PET brain scan, CSF biomarkers measurement and APOE genotype analysis at baseline and underwent neurological follow-up for a mean time of 3 years. Patients who progressed to total loss of speech (TLoS + ) had greater impairment in writing and higher t-tau concentration as compared to TLoS - patients. Patients who progressed to loss of functional autonomy (LoFA + ) had greater impairment in single-word comprehension as compared to patients who maintained autonomy in self-care. Furthermore, 18 F-FDG-PET SPM analyses revealed different brain metabolic patterns between TLoS + and TLoS - and between LoFA + and LoFA - . In conclusion, linguistic profile, CSF t-tau and brain metabolic pattern might be useful tools to predict progression to total loss of speech and loss of functional autonomy in AD-related PPA patients.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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