Genoprotective effect of cornelian cherry (Cornus mas L.) phytochemicals, electrochemical and ab initio interaction study.

Autor: Szczepaniak O; Department of Gastronomy Sciences and Functional Foods, Poznań University of Life Sciences, Poland. Electronic address: oskar.szczepaniak@up.poznan.pl., Ligaj M; Department of Non-Food Products Quality and Packaging Development, Poznań University of Economics and Business, Poland., Stuper-Szablewska K; Department of Chemistry, Poznań University of Life Sciences, Poland., Kobus-Cisowska J; Department of Gastronomy Sciences and Functional Foods, Poznań University of Life Sciences, Poland.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Aug; Vol. 152, pp. 113216. Date of Electronic Publication: 2022 Jun 02.
DOI: 10.1016/j.biopha.2022.113216
Abstrakt: Cornelian cherry (Cornus mas L.) has broad and multidimensional potential in preventing civilisational diseases. Part of these diseases results from DNA oxidative mutations. Thus, the paper aimed to predict how phenolics present in C. mas may interact with dsDNA in ab initio experiment and to check the effect of different cornelian cherry extracts on DNA structure and DNA oxidation. A special research model was designed using biosensor with a carbonpaste electrode. We resulted in various effects observed for phenolics and the extracts. Flavonoids, but of vitexin interacted with declining energy of the DNA models and liability of DNA oxidation. However, for 8-oxoguaniosine the trend was the opposite. Among the evaluated extracts, water-ethanolic extracts caused decline in adenine and guanine signals after dsDNA exposition on the extract. Principal component analysis showed that alcoholic extracts of cv. Szafer and Słowianin, which were rich in apigenin and kaempferol exhibit mild genoprotective effect.
(Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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