Epidemiologic and Genomic Analysis of the Severe Acute Respiratory Syndrome Coronavirus 2 Epidemic in the Nebraska Region of the United States, March 2020-2021.

Autor:	Siedlik JA; Department of Exercise Science and Pre-Health Professions, Creighton University, Omaha, NE, United States., Watson CJ; Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE, United States., Raine MA; Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE, United States., Cheng AV; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, United States., Goering RV; Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE, United States., Stessman HAF; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, United States., Belshan M; Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in microbiology [Front Microbiol] 2022 May 18; Vol. 13, pp. 878342. Date of Electronic Publication: 2022 May 18 (Print Publication: 2022).
DOI:	10.3389/fmicb.2022.878342
Abstrakt:	COVID-19 emerged at varying intervals in different regions of the United States in 2020. This report details the epidemiologic and genetic evolution of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first year of the epidemic in the state of Nebraska using data collected from the Creighton Catholic Health Initiatives (CHI) health system. Statistical modelling identified age, gender, and previous history of diabetes and/or stroke as significant risk factors associated with mortality in COVID-19 patients. In parallel, the viral genomes of over 1,000 samples were sequenced. The overall rate of viral variation in the population was 0.07 mutations/day. Genetically, the first 9 months of the outbreak, which include the initial outbreak, a small surge in August and a major outbreak in November 2020 were primarily characterized by B.1. lineage viruses. In early 2021, the United Kingdom variant (B.1.1.7 or alpha) quickly became the dominant variant. Notably, surveillance of non-consensus variants detected B.1.1.7 defining mutations months earlier in Fall 2020. This work provides insights into the regional variance and evolution of SARS-CoV-2 in the Nebraska region during the first year of the pandemic. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Siedlik, Watson, Raine, Cheng, Goering, Stessman and Belshan.)
Databáze:	MEDLINE
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