Intraoperative microseizure detection using a high-density micro-electrocorticography electrode array.

Autor:	Sun J; Center for Neural Science, New York University, New York, NY, USA., Barth K; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Qiao S; Center for Neural Science, New York University, New York, NY, USA., Chiang CH; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Wang C; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Rahimpour S; Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.; Department of Neurosurgery, Clinical Neuroscience Center, University of Utah, Salt Lake City, UT, USA., Trumpis M; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Duraivel S; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Dubey A; Center for Neural Science, New York University, New York, NY, USA., Wingel KE; Center for Neural Science, New York University, New York, NY, USA., Rachinskiy I; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Voinas AE; Center for Neural Science, New York University, New York, NY, USA., Ferrentino B; Center for Neural Science, New York University, New York, NY, USA., Southwell DG; Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.; Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA., Haglund MM; Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA., Friedman AH; Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA., Lad SP; Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA., Doyle WK; Department of Neurosurgery, NYU Grossman School of Medicine, New York, NY, USA., Solzbacher F; Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, USA.; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.; Department of Materials Science & Engineering, University of Utah, Salt Lake City, UT, USA., Cogan G; Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.; Center for Cognitive Neuroscience, Duke University, Durham, NC, USA.; Duke Comprehensive Epilepsy Center, Duke University School of Medicine, Durham, NC, USA.; Department of Neurology, Duke University School of Medicine, Durham, NC, USA., Sinha SR; Duke Comprehensive Epilepsy Center, Duke University School of Medicine, Durham, NC, USA.; Department of Neurology, Duke University School of Medicine, Durham, NC, USA., Devore S; Department of Neurology, NYU Grossman School of Medicine, New York, NY, USA., Devinsky O; Department of Neurosurgery, NYU Grossman School of Medicine, New York, NY, USA.; Department of Neurology, NYU Grossman School of Medicine, New York, NY, USA.; Department of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA., Friedman D; Department of Neurology, NYU Grossman School of Medicine, New York, NY, USA., Pesaran B; Center for Neural Science, New York University, New York, NY, USA.; Department of Neurology, NYU Grossman School of Medicine, New York, NY, USA., Viventi J; Department of Biomedical Engineering, Duke University, Durham, NC, USA.; Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.; Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA.; Duke Comprehensive Epilepsy Center, Duke University School of Medicine, Durham, NC, USA.
Jazyk:	angličtina
Zdroj:	Brain communications [Brain Commun] 2022 May 27; Vol. 4 (3), pp. fcac122. Date of Electronic Publication: 2022 May 27 (Print Publication: 2022).
DOI:	10.1093/braincomms/fcac122
Abstrakt:	One-third of epilepsy patients suffer from medication-resistant seizures. While surgery to remove epileptogenic tissue helps some patients, 30-70% of patients continue to experience seizures following resection. Surgical outcomes may be improved with more accurate localization of epileptogenic tissue. We have previously developed novel thin-film, subdural electrode arrays with hundreds of microelectrodes over a 100-1000 mm 2 area to enable high-resolution mapping of neural activity. Here, we used these high-density arrays to study microscale properties of human epileptiform activity. We performed intraoperative micro-electrocorticographic recordings in nine patients with epilepsy. In addition, we recorded from four patients with movement disorders undergoing deep brain stimulator implantation as non-epileptic controls. A board-certified epileptologist identified microseizures, which resembled electrographic seizures normally observed with clinical macroelectrodes. Recordings in epileptic patients had a significantly higher microseizure rate (2.01 events/min) than recordings in non-epileptic subjects (0.01 events/min; permutation test, P  = 0.0068). Using spatial averaging to simulate recordings from larger electrode contacts, we found that the number of detected microseizures decreased rapidly with increasing contact diameter and decreasing contact density. In cases in which microseizures were spatially distributed across multiple channels, the approximate onset region was identified. Our results suggest that micro-electrocorticographic electrode arrays with a high density of contacts and large coverage are essential for capturing microseizures in epilepsy patients and may be beneficial for localizing epileptogenic tissue to plan surgery or target brain stimulation. (© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.)
Databáze:	MEDLINE
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