The effects of lateral pharyngoplasty on carotid intima-media thickness in patients with obstructive sleep apnoea.

Autor: Iglesias ÉP; Hospital do Servidor Público Estadual de São Paulo, Department of Otolaryngology - São Paulo - Brazil., Cahali MB; Hospital do Servidor Público Estadual de São Paulo, Department of Otolaryngology - São Paulo - Brazil.; Universidade de São Paulo, Department of Otolaryngology - São Paulo - Brazil.
Jazyk: angličtina
Zdroj: Sleep science (Sao Paulo, Brazil) [Sleep Sci] 2022 Jan-Mar; Vol. 15 (1), pp. 82-87.
DOI: 10.5935/1984-0063.20220028
Abstrakt: Introduction: Obstructive sleep apnea (OSA) is a known risk factor for development of carotid atherosclerosis. The treatment of OSA, through positive pressure devices or surgical procedures, may reduce the signs of subclinical atherosclerosis in apneic patients.
Objective: The decrease of carotid intima-media thickness (CIMT) after treatment of OSA remains a highly controversial issue. Our purpose is to compare CIMT, which represents an early sign of atherosclerosis, before and at least 6 months after lateral pharyngoplasty in patients with OSA.
Material and Methods: A total of 17 patients with OSA who underwent lateral pharyngoplasty were submitted to common carotid Doppler ultrasonography, 24-hour ambulatory blood pressure monitoring and type-1 polysomnography before and at least 6 months after surgery.
Results: The median apnoea-hypopnoea index decreased from 22.6 to 5.9 (p<0.001). There were significant improvements in the arousal index, minimum oxyhaemoglobin saturation, Epworth sleepiness scale and reported snoring intensity. The surgical success rate (Shers criteria) obtained with the procedure was 76.4%. There was no significant variation in the mean CIMT after surgeries (right carotid artery, mean, 0.67 and 0.72 mm; left carotid artery, mean, 0.69 and 0.70 mm, pre- and postoperative, respectively, both p>0.05). Blood pressure measurements also did not significantly change.
Conclusion: Notwithstanding a significant improvement in OSA after lateral pharyngoplasty, there was no significant reduction in CIMT in a follow-up of 6 months.
Databáze: MEDLINE