Epidemiological and clinical characteristics of pregnant women and neonates with COVID-19 in Northwest Mexico.

Autor: Leon-Sicairos N; CIASaP, School of Medicine, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico.; Pediatric Hospital of Sinaloa, Culiacan, Sinaloa, Mexico., Angulo-Zamudio UA; CIASaP, School of Medicine, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico., Pacheco-Avila M; The Women's Hospital, Secretariat of Health, Culiacan, Sinaloa, Mexico., Medina-Ramirez I; The Women's Hospital, Secretariat of Health, Culiacan, Sinaloa, Mexico., Velazquez-Roman J; CIASaP, School of Medicine, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico., Angulo-Rocha J; The Women's Hospital, Secretariat of Health, Culiacan, Sinaloa, Mexico., Martínez-Villa FA; CIASaP, School of Medicine, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico., Flores-Villaseñor H; CIASaP, School of Medicine, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico.; The Sinaloa State Public Health Laboratory, Secretariat of Health, Culiacan, Sinaloa, Mexico., Martinez-Garcia JJ; CIASaP, School of Medicine, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico.; Pediatric Hospital of Sinaloa, Culiacan, Sinaloa, Mexico., Sanchez-Cuen J; CIASaP, School of Medicine, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico., Garzon-Lopez O; The Women's Hospital, Secretariat of Health, Culiacan, Sinaloa, Mexico., Guel-Gomez M; The Women's Hospital, Secretariat of Health, Culiacan, Sinaloa, Mexico., Cuen-Diaz HM; FCA, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico., Barajas-Olivas MF; The Women's Hospital, Secretariat of Health, Culiacan, Sinaloa, Mexico., Campos-Romero A; Salud Digna A.C., Culiacán, Sinaloa, México., Alcántar-Fernández J; Salud Digna A.C., Culiacán, Sinaloa, México., Esparza MAL; Salud Digna A.C., Culiacán, Sinaloa, México., Canizalez-Roman A; CIASaP, School of Medicine, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico.; The Women's Hospital, Secretariat of Health, Culiacan, Sinaloa, Mexico.
Jazyk: angličtina
Zdroj: American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2022 Sep; Vol. 88 (3), pp. e13583. Date of Electronic Publication: 2022 Jun 10.
DOI: 10.1111/aji.13583
Abstrakt: Introduction: The SARS-CoV-2 virus, which causes COVID-19, has spread quickly worldwide, causing millions of cases and thousands of deaths. Some risk factors in the general population are related to the development of severe COVID-19 or death, but in pregnant women and neonates, the information is limited.
Objective: To determine the epidemiological and clinical characteristics of pregnant women and neonates diagnosed with COVID-19 by RT-PCR and serological tests, and analyze the relationship between the influenza vaccination and COVID-19 symptoms in infected pregnant women in Sinaloa state.
Methods: We collected samples from 116 pregnant women and 84 neonates from the Women´s Hospital of Sinaloa. They were diagnosed with COVID-19 by RT-PCR and serological tests (IgG), and sociodemographic, clinical and laboratory parameters were recorded.
Results: A total of 11.2% (13/116) of the pregnant women were RT-PCR+, 25% (29/116) were IgG+ and 4.3% (5/116) were positive for both tests. Symptoms such as rhinorrhea (P = .04), cough (P = .02) and polypnea (P = .04) in pregnant women were related to COVID-19, also leukocyte index was higher in pregnant women with COVID-19 (P = .03), but the associations were lost after the Bonferroni correction. No laboratory parameters or underlying diseases were associated with COVID-19, and most infected pregnant women had mild cases. We found an association between the influenza vaccine and less common COVID-19 symptoms in pregnant women who were infected (P = .01). A total of 7.2% (6/84) of neonates were RT-PCR+, 35.7% (30/84) were IgG+, and there were no symptoms or underlying diseases associated with neonates who were infected. In conclusion, this work demonstrated that some symptoms were related to COVID-19, most pregnant women and neonates had mild cases, and the influenza vaccine could decrease the severity of COVID-19 cases in pregnant women.
(© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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