Association between being underweight and excess body weight before SARS coronavirus type 2 infection and clinical outcomes of coronavirus disease 2019: Multicenter study.

Autor: Barros-Neto JA; Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil. Electronic address: joao.neto@fanut.ufal.br., Mello CS; Escola de Nutrição, Universidade Federal da Bahia, Salvador, Bahia, Brazil., Vasconcelos SML; Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., Bádue GS; Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., Ferreira RC; Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil; Curso de Nutrição, Centro Universitário Tiradentes, Maceió, Alagoas, Brazil., Andrade MIS; Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., Nascimento CQD; Escola de Enfermagem, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., Macena ML; Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., Silva JAD; Faculdade de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Santa Cruz, Rio Grande do Norte, Brazil., Clemente HA; Faculdade de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Santa Cruz, Rio Grande do Norte, Brazil., Petribu MMV; Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Vitória de Santo Antão, Pernambuco, Brazil., Dourado KF; Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Vitória de Santo Antão, Pernambuco, Brazil., Pinho CPS; Hospital das Clínicas de Pernambuco, Recife, Pernambuco, Brazil., Vieira RAL; Escola de Nutrição, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Mello LB; Escola de Nutrição, Universidade Federal da Bahia, Salvador, Bahia, Brazil., Neves MBD; Escola de Nutrição, Universidade Federal da Bahia, Salvador, Bahia, Brazil., Jesus CA; Escola de Nutrição, Universidade Federal da Bahia, Salvador, Bahia, Brazil., Santos TMPD; Curso de Nutrição, Centro Universitário Tiradentes, Maceió, Alagoas, Brazil., Soares BLM; Hospital da Restauração, Recife, Pernambuco, Brazil., Medeiros LB; Faculdade de Santa Maria de Cajazeiras, Cajazeiras, Paraíba, Brazil; Facudade de Integração do Sertão, Serra Talhada, Pernambuco, Brazil., França AP; Facudade de Integração do Sertão, Serra Talhada, Pernambuco, Brazil., Sales ALCC; Hospital Universitário do Piauí, Teresina, Piauí, Brazil., Furtado EVH; Curso de Nutrição, Universidade Federal do Maranhão, São Luís, Maranhão, Brazil., Oliveira AC; Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., Farias FO; Escola de Nutrição, Universidade Federal da Bahia, Salvador, Bahia, Brazil., Freitas MC; Escola de Nutrição, Universidade Federal da Bahia, Salvador, Bahia, Brazil., Bueno NB; Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil.
Jazyk: angličtina
Zdroj: Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2022 Sep; Vol. 101, pp. 111677. Date of Electronic Publication: 2022 Apr 01.
DOI: 10.1016/j.nut.2022.111677
Abstrakt: Objectives: The present study aimed to identify associations between extremes in body weight status (underweight and excess body weight) before a COVID-19 diagnosis and clinical outcomes in patients infected with SARS coronavirus type 2.
Methods: A multicenter cohort study was conducted in eight different states in northeastern Brazil. Demographic, clinical (previous diagnosis of comorbidities), and anthropometric (self-reported weight and height) data about individuals who tested positive for COVID-19 were collected. Outcomes included hospitalization, mechanical ventilation, and death. Multivariable logistic regression models, adjusted based on age, sex and previous comorbidities, were used to assess the effects of extremes in body weight status on clinical outcomes.
Results: A total of 1308 individuals were assessed (33.6% were elderly individuals). The univariable analyses showed that only hospitalization was more often observed among underweight (3.2% versus 1.2%) and overweight (68.1% versus 63.3%) individuals. In turn, cardiovascular diseases were more often observed in all clinical outcomes (hospitalization: 19.7% versus 4.8%; mechanical ventilation: 19.9% versus 13.5%; death: 21.8% versus 14.1%). Based on the multivariable analysis, body weight status was not associated with risk of hospitalization (underweight: odds ratio [OR]: 1.10; 95% confidence interval [CI] 95%, 0.50-2.41 and excess body weight: OR: 0.81; 95 CI, 0.57-1.14), mechanical ventilation (underweight: OR: 0.92; 95% CI, 0.52-1.62 and excess weight: OR: 0.90; 95% CI, 0.67-1.19), and death (underweight: OR: 0.61; 95% CI, 0.31-1.20 and excess body weight: OR 0.88; 95% CI, 0.63-1.23).
Conclusions: Being underweight and excess body weight were not independently associated with clinical outcomes in patients with COVID-19 in the herein analyzed cohort. This finding indicates that the association between these variables may be confounded by both age and comorbidities.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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