Nitric oxide and long-term outcomes after kidney transplantation: Results of the TransplantLines cohort study.

Autor: Maassen H; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, the Netherlands., Said MY; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, the Netherlands., Frenay AS; Department of Gynecology and Obstetrics, Amsterdam University Medical Center, University of Amsterdam, the Netherlands., Koning A; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, the Netherlands., Post A; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, the Netherlands., Riphagen IJ; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Heiner-Fokkema MR; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Drabert K; Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, Hannover, Germany., Fernandez BO; Clinical & Experimental Sciences, Faculty of Medicine and NIHR Southampton Biomedical Research Centre, Southampton General Hospital, United Kingdom., Gans ROB; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, the Netherlands., van den Berg E; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, the Netherlands., Navis G; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, the Netherlands., Tsikas D; Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, Hannover, Germany., Feelisch M; Clinical & Experimental Sciences, Faculty of Medicine and NIHR Southampton Biomedical Research Centre, Southampton General Hospital, United Kingdom., Bakker SJL; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, the Netherlands., van Goor H; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, the Netherlands. Electronic address: h.van.goor@umcg.nl.
Jazyk: angličtina
Zdroj: Nitric oxide : biology and chemistry [Nitric Oxide] 2022 Aug 01; Vol. 125-126, pp. 1-11. Date of Electronic Publication: 2022 Jun 02.
DOI: 10.1016/j.niox.2022.05.005
Abstrakt: Impaired endogenous nitric oxide (NO) production may contribute to graft failure and premature mortality in kidney transplant recipients (KTR). We investigated potential associations of 24-h urinary NOx (NO 3 -  + NO 2 - ) excretion (uNOx) with long-term outcomes. uNOx was determined by HPLC and GC-MS in 698 KTR and in 132 kidney donors before and after donation. Additionally, we measured urinary nitroso species (RXNO) by gas-phase chemiluminescence. Median uNOx was lower in KTR compared to kidney donors (688 [393-1076] vs. 1301 [868-1863] before donation and 1312 [982-1853] μmol/24 h after donation, P < 0.001). During median follow-up of 5.4 [4.8-6.1] years, 150 KTR died (61 due to cardiovascular disease) and 83 experienced graft failure. uNOx was inversely associated with all-cause mortality (HR per doubling of uNOx: 0.84 [95% CI 0.75-0.93], P < 0.001) and cardiovascular mortality (HR 0.78 [95% CI 0.67-0.92], P = 0.002). The association of uNOx with graft failure was lost when adjusted for renal function (HR per doubling of uNOx: 0.89 [95% CI 0.76-1.05], P = 0.17). There were no significant associations of urinary RXNO with outcomes. Our study suggests that KTR have lower NO production than healthy subjects and that lower uNOx is associated with a higher risk of all-cause and cardiovascular mortality.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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