Anastasis: cell recovery mechanisms and potential role in cancer.

Autor: Mohammed RN; Medical Laboratory Analysis Department, College of Health Sciences, Cihan University of Sulaimaniya, Kurdistan Region, Sulaimaniya, Iraq.; College of Veterinary Medicine, University of Sulaimani, Sulaimaniyah, Iraq., Khosravi M; Department of Psychiatry and Clinical Psychology, Zahedan University of Medical Sciences, Zahedan, Iran., Rahman HS; Department of Physiology, College of Medicine, University of Sulaimani, Sulaimaniyah, Iraq.; Department of Medical Laboratory Sciences, Komar University of Science and Technology, Sarchinar District, Sulaimaniyah, Iraq., Adili A; Department of Oncology, Tabriz University of Medical Sciences, Tabriz, Iran., Kamali N; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Soloshenkov PP; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. pavelsoloshenkov@yandex.ru., Thangavelu L; Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, India., Saeedi H; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Shomali N; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Tamjidifar R; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Isazadeh A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Aslaminabad R; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Akbari M; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. akbarimo@tbzmed.ac.ir.
Jazyk: angličtina
Zdroj: Cell communication and signaling : CCS [Cell Commun Signal] 2022 Jun 03; Vol. 20 (1), pp. 81. Date of Electronic Publication: 2022 Jun 03.
DOI: 10.1186/s12964-022-00880-w
Abstrakt: Balanced cell death and survival are among the most important cell development and homeostasis pathways that can play a critical role in the onset or progress of malignancy steps. Anastasis is a natural cell recovery pathway that rescues cells after removing the apoptosis-inducing agent or brink of death. The cells recuperate and recover to an active and stable state. So far, minimal knowledge is available about the molecular mechanisms of anastasis. Still, several involved pathways have been explained: recovery through mitochondrial outer membrane permeabilization, caspase cascade arrest, repairing DNA damage, apoptotic bodies formation, and phosphatidylserine. Anastasis can facilitate the survival of damaged or tumor cells, promote malignancy, and increase drug resistance and metastasis. Here, we noted recently known mechanisms of the anastasis process and underlying molecular mechanisms. Additionally, we summarize the consequences of anastatic mechanisms in the initiation and progress of malignancy, cancer cell metastasis, and drug resistance. Video Abstract.
(© 2022. The Author(s).)
Databáze: MEDLINE
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