Impact of a spatial repellent product on Anopheles and non-Anopheles mosquitoes in Sumba, Indonesia.

Autor: Permana DH; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Diponegoro 69, Jakarta Pusat, 10430, Indonesia., Zubaidah S; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Diponegoro 69, Jakarta Pusat, 10430, Indonesia., Syahrani L; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Diponegoro 69, Jakarta Pusat, 10430, Indonesia., Asih PBS; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Diponegoro 69, Jakarta Pusat, 10430, Indonesia., Syafruddin D; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Diponegoro 69, Jakarta Pusat, 10430, Indonesia. dinkarim@yahoo.com.; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. dinkarim@yahoo.com., Rozi IE; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Diponegoro 69, Jakarta Pusat, 10430, Indonesia., Hidayati APN; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Diponegoro 69, Jakarta Pusat, 10430, Indonesia., Kosasih S; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Diponegoro 69, Jakarta Pusat, 10430, Indonesia., Dewayanti FK; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Diponegoro 69, Jakarta Pusat, 10430, Indonesia., Rachmawati N; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Diponegoro 69, Jakarta Pusat, 10430, Indonesia., Risandi R; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Diponegoro 69, Jakarta Pusat, 10430, Indonesia., Bangs MJ; Public Health and Malaria Control, PT Freeport Indonesia, International SOS, Kuala Kencana, Papua, Indonesia.; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand., Bøgh C; The Sumba Foundation, Public Health and Malaria Control, Bali, Indonesia., Davidson JR; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA., Hendershot AL; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA., Burton TA; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA., Grieco JP; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA., Eugenio EC; Sandia National Laboratories, Albuquerque, NM, USA., Liu F; Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN, USA., Achee NL; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA., Lobo NF; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA.
Jazyk: angličtina
Zdroj: Malaria journal [Malar J] 2022 Jun 03; Vol. 21 (1), pp. 166. Date of Electronic Publication: 2022 Jun 03.
DOI: 10.1186/s12936-022-04185-8
Abstrakt: Background: The East Nusa Tenggara province, Indonesia, contributed to 5% of malaria cases nationally in 2020, with other mosquito-borne diseases, such as dengue and filariasis also being endemic. Monitoring of spatial and temporal vector species compositions and bionomic traits is an efficient method for generating evidence towards intervention strategy optimization and meeting disease elimination goals.
Methods: The impact of a spatial repellent (SR) on human biting mosquitoes was evaluated as part of a parent cluster-randomized, double-blinded, placebo-controlled trial, in Sumba, East Nusa Tenggara. A 10-month (June 2015-March 2016) baseline study was followed by a 24-month intervention period (April 2016 to April 2018)-where half the clusters were randomly assigned either a passive transfluthrin emanator or a placebo control.
Results: Human-landing mosquito catches documented a reduction in landing rates related to the SR. Overall, there was a 16.4% reduction (21% indoors, and 11.3% outdoors) in human biting rates (HBR) for Anopheles. For Aedes, there was a 44.3% HBR reduction indoors and a 35.6% reduction outdoors. This reduction was 38.3% indoors and 39.1% outdoors for Armigeres, and 36.0% indoors and 32.3% outdoors for Culex species. Intervention impacts on the HBRs were not significant and are attributed to large inter-household and inter cluster variation. Anopheles flavirostris, Anopheles balabacensis and Anopheles maculatus individually impacted the overall malaria infections hazard rate with statistically significance. Though there was SR-based protection against malaria for all Anopheles species (except Anopheles sundaicus), only five (Anopheles aconitus, Anopheles kochi, Anopheles tessellatus, An. maculatus and An. sundaicus) demonstrated statistical significance. The SR numerically reduced Anopheles parity rates indoors and outdoors when compared to the placebo.
Conclusion: Evidence demonstrating that Anopheles vectors bite both indoors and outdoors indicates that currently implemented indoor-based vector control tools may not be sufficient to eliminate malaria. The documented impact of the SR intervention on Aedes, Armigeres and Culex species points to its importance in combatting other vector borne diseases. Studies to determine the impact of spatial repellents on other mosquito-borne diseases is recommended.
(© 2022. The Author(s).)
Databáze: MEDLINE
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