Suppression of HCT116 Human Colon Cancer Cell Motility by Polymethoxyflavones is Associated with Inhibition of Wnt/β-Catenin Signaling.

Autor: Hino SI; Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan., Inenaga K; Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan., Miyazaki T; Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan., Tanaka-Mizota C; Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.
Jazyk: angličtina
Zdroj: Nutrition and cancer [Nutr Cancer] 2022; Vol. 74 (10), pp. 3662-3669. Date of Electronic Publication: 2022 Jun 06.
DOI: 10.1080/01635581.2022.2084122
Abstrakt: Aberrant regulation of the Wnt/β-catenin signaling pathway is one of the major causes of colorectal cancer (CRC). In this study, we examined the effect of polymethoxyflavones present in citrus peels on Wnt/β-catenin signaling in the HCT116 CRC cell line. We found that 5,7,3',4'-tetra-methoxyflavone (TMF) and 7,8,3',4'-TMF inhibited the expression of target genes of Wnt/β-catenin signaling and the transcriptional activities of β-catenin/Tcf and suppressed the motility of HCT116 cells. Because the binding of β-catenin to Tcf-4 was disrupted by 5,7,3',4'-TMF and 7,8,3',4'- TMF, we suggest that they are inhibitors of the Wnt/β-catenin signaling and may have potential applications in CRC prevention.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje