Palladium-catalyzed chemoselective direct α-arylation of carbonyl compounds with chloroaryl triflates at the C-Cl site.
| Autor: | Chen Z; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Kowloon Hong Kong SAR China chau.ming.so@polyu.edu.hk., Gu C; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Kowloon Hong Kong SAR China chau.ming.so@polyu.edu.hk., Yuen OY; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Kowloon Hong Kong SAR China chau.ming.so@polyu.edu.hk., So CM; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Kowloon Hong Kong SAR China chau.ming.so@polyu.edu.hk.; The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057 Guangdong China. |
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| Jazyk: | angličtina |
| Zdroj: | Chemical science [Chem Sci] 2022 Mar 16; Vol. 13 (17), pp. 4762-4769. Date of Electronic Publication: 2022 Mar 16 (Print Publication: 2022). |
| DOI: | 10.1039/d1sc06701j |
| Abstrakt: | This study described palladium-catalyzed chemoselective direct α-arylation of carbonyl compounds with chloroaryl triflates in the Ar-Cl bond. The Pd/SelectPhos system showed excellent chemoselectivity toward the Ar-Cl bond in the presence of the Ar-OTf bond with a broad substrate scope and excellent product yields. The electronic and steric hindrance offered by the -PR Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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