Synchrony and idiosyncrasy in the gut microbiome of wild baboons.

Autor: Björk JR; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. bjork.johannes@gmail.com., Dasari MR; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA., Roche K; Program in Computational Biology and Bioinformatics, Duke University, Durham, NC, USA., Grieneisen L; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA., Gould TJ; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA., Grenier JC; Department of Genetics, CHU Sainte Justine Research Center, Montréal, Quebec, Canada.; Research Center, Montreal Heart Institute, Montréal, Quebec, Canada., Yotova V; Department of Genetics, CHU Sainte Justine Research Center, Montréal, Quebec, Canada., Gottel N; Department of Pediatrics and the Scripps Institution of Oceanography, University of California, San Diego, San Diego, CA, USA., Jansen D; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA., Gesquiere LR; Department of Biology, Duke University, Durham, NC, USA., Gordon JB; Department of Biology, Duke University, Durham, NC, USA., Learn NH; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA., Wango TL; Amboseli Baboon Research Project, Amboseli National Park, Amboseli, Kenya.; The Department of Veterinary Anatomy and Animal Physiology, University of Nairobi, Nairobi, Kenya., Mututua RS; Amboseli Baboon Research Project, Amboseli National Park, Amboseli, Kenya., Kinyua Warutere J; Amboseli Baboon Research Project, Amboseli National Park, Amboseli, Kenya., Siodi L; Amboseli Baboon Research Project, Amboseli National Park, Amboseli, Kenya., Mukherjee S; Program in Computational Biology and Bioinformatics, Duke University, Durham, NC, USA., Barreiro LB; Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA., Alberts SC; Department of Biology, Duke University, Durham, NC, USA.; Department of Evolutionary Anthropology, Duke University, Durham, NC, USA.; Duke University Population Research Institute, Duke University, Durham, NC, USA., Gilbert JA; Department of Pediatrics and the Scripps Institution of Oceanography, University of California, San Diego, San Diego, CA, USA., Tung J; Department of Biology, Duke University, Durham, NC, USA.; Department of Evolutionary Anthropology, Duke University, Durham, NC, USA.; Duke University Population Research Institute, Duke University, Durham, NC, USA.; Canadian Institute for Advanced Research, Toronto, Ontario, Canada., Blekhman R; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA.; Department of Ecology, Evolution, and Behavior, University of Minnesota, Minneapolis, MN, USA., Archie EA; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. earchie@nd.edu.
Jazyk: angličtina
Zdroj: Nature ecology & evolution [Nat Ecol Evol] 2022 Jul; Vol. 6 (7), pp. 955-964. Date of Electronic Publication: 2022 Jun 02.
DOI: 10.1038/s41559-022-01773-4
Abstrakt: Human gut microbial dynamics are highly individualized, making it challenging to link microbiota to health and to design universal microbiome therapies. This individuality is typically attributed to variation in host genetics, diets, environments and medications but it could also emerge from fundamental ecological forces that shape microbiota more generally. Here, we leverage extensive gut microbial time series from wild baboons-hosts who experience little interindividual dietary and environmental heterogeneity-to test whether gut microbial dynamics are synchronized across hosts or largely idiosyncratic. Despite their shared lifestyles, baboon microbiota were only weakly synchronized. The strongest synchrony occurred among baboons living in the same social group, probably because group members range over the same habitat and simultaneously encounter the same sources of food and water. However, this synchrony was modest compared to each host's personalized dynamics. In support, host-specific factors, especially host identity, explained, on average, more than three times the deviance in longitudinal dynamics compared to factors shared with social group members and ten times the deviance of factors shared across the host population. These results contribute to mounting evidence that highly idiosyncratic gut microbiomes are not an artefact of modern human environments and that synchronizing forces in the gut microbiome (for example, shared environments, diets and microbial dispersal) are not strong enough to overwhelm key drivers of microbiome personalization, such as host genetics, priority effects, horizontal gene transfer and functional redundancy.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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