The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine.

Autor: Lawrence-Mills SJ; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK; current affiliation The Royal Veterinary College, University of London, North Mimms, UK. Electronic address: slawrencemills21@rvc.ac.uk., Hughes D; Bristol Veterinary School, University of Bristol, Langford, UK., Hezzell MJ; Bristol Veterinary School, University of Bristol, Langford, UK., Butler M; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Neal C; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Foster RR; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Welsh GI; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Finch N; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK; Bristol Veterinary School, University of Bristol, Langford, UK; Langford Vets, Langford House, Langford, UK.
Jazyk: angličtina
Zdroj: Veterinary journal (London, England : 1997) [Vet J] 2022 Jul; Vol. 285, pp. 105843. Date of Electronic Publication: 2022 May 30.
DOI: 10.1016/j.tvjl.2022.105843
Abstrakt: The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its structure, essential functions, and evidence for its role in disease. We highlight the lack of studies regarding the eGlx in cats and dogs, particularly in naturally occurring diseases. Importantly, we discuss techniques to aid its study, which can be applied to veterinary species. Finally, we present targeted therapies aimed at preserving, and in some cases, restoring damaged eGlx.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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