Lipophagy pathways in yeast are controlled by their distinct modes of induction.

Autor: Fairman G; University of Ottawa Heart Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada., Ouimet M; University of Ottawa Heart Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Jazyk: angličtina
Zdroj: Yeast (Chichester, England) [Yeast] 2022 Aug; Vol. 39 (8), pp. 429-439. Date of Electronic Publication: 2022 Jun 02.
DOI: 10.1002/yea.3705
Abstrakt: Lipid droplet (LD) autophagy (lipophagy) is a recently discovered selective form of autophagy and is a pathway for LD catabolism. This ubiquitous process has been an ongoing area of research within the budding yeast, Saccharomyces cerevisiae. Yeast lipophagy phenotypically resembles microautophagy, although it has a distinct set of genetic requirements depending on the mode of induction. This review highlights the similarities and differences between different forms of yeast lipophagy and offers perspectives on how our knowledge of lipophagy in yeast may guide our understanding of this process within mammalian cells to ultimately inform future applications of lipophagy.
(© 2022 John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: