The risk factors for radial artery and saphenous vein graft occlusion are different.

Autor: Bahar R; Department of Cardiothoracic and Vascular Surgery and Department of Cardiology, University Hospital North Norway, Tromsø, Norway., Hermansen SE; Department of Cardiothoracic and Vascular Surgery and Department of Cardiology, University Hospital North Norway, Tromsø, Norway., Dahl-Eriksen Ø; Department of Cardiology, University Hospital North Norway, Tromsø, Norway., Busund R; Department of Cardiothoracic and Vascular Surgery and Department of Cardiology, University Hospital North Norway, Tromsø, Norway.; Institute of Clinical Medicine, University of Tromsø The Arctic University of Norway, Tromsø, Norway., Dahl PE; Department of Cardiothoracic and Vascular Surgery and Department of Cardiology, University Hospital North Norway, Tromsø, Norway., Iqbal A; Department of Cardiology, University Hospital North Norway, Tromsø, Norway., Mannsverk JT; Department of Cardiology, University Hospital North Norway, Tromsø, Norway., Myrmel T; Department of Cardiothoracic and Vascular Surgery and Department of Cardiology, University Hospital North Norway, Tromsø, Norway.; Institute of Clinical Medicine, University of Tromsø The Arctic University of Norway, Tromsø, Norway., Steigen TK; Department of Cardiology, University Hospital North Norway, Tromsø, Norway.; Institute of Clinical Medicine, University of Tromsø The Arctic University of Norway, Tromsø, Norway., Trovik TS; Department of Cardiology, University Hospital North Norway, Tromsø, Norway., Sørlie DG; Department of Cardiothoracic and Vascular Surgery and Department of Cardiology, University Hospital North Norway, Tromsø, Norway.; Institute of Clinical Medicine, University of Tromsø The Arctic University of Norway, Tromsø, Norway., Bartnes K; Department of Cardiothoracic and Vascular Surgery and Department of Cardiology, University Hospital North Norway, Tromsø, Norway.; Institute of Clinical Medicine, University of Tromsø The Arctic University of Norway, Tromsø, Norway.
Jazyk: angličtina
Zdroj: Scandinavian cardiovascular journal : SCJ [Scand Cardiovasc J] 2022 Dec; Vol. 56 (1), pp. 127-131.
DOI: 10.1080/14017431.2022.2079716
Abstrakt: Objectives. To determine risk factors for radial artery and saphenous vein graft occlusion during long-term follow-up after coronary artery bypass grafting (CABG). Methods: From a cohort of 119 patients who had received a radial artery graft, 76 - of whom 55 also had at least one saphenous vein graft - underwent a preplanned direct angiography and anthropometric, biochemical, and endothelial function assessment 7.6-12.1 (mean 8.9) years after CABG. Comorbidity, medication, and smoking habits were also recorded. The association between these parameters and conduit longevity was analyzed in univariable and multivariable logistic regression models. Results: Radial artery graft occlusions were associated with higher plasma levels of high-sensitive C-reactive protein and patency was best among patients with pharmacologically treated hypertension. The sole independent risk factor identified for saphenous vein graft occlusion was tobacco smoking 8-12 years postoperatively. Conclusion: Our data support the contention that the pathogenesis of radial artery graft failure is distinct from vein graft disease and is related to hypertension status and systemic inflammation. These risk factors are potential targets for preventive measures. Accordingly, the study supports the eventual design of personalized secondary prevention regimens. Clinical registration number: ISRCTN23118170.
Databáze: MEDLINE
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