Chemotherapeutic Activities of Dietary Phytoestrogens against Prostate Cancer: From Observational to Clinical Studies.

Autor:	Sohel M; Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Santosh, Tangail- 1902, Bangladesh.; Pratyasha Health Biomedical Research Center, Dhaka-1230. Bangladesh., Sultana H; Department of Biotechnology and Genetic Engineering, Faculty of life science, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh., Sultana T; Department of Biotechnology and Genetic Engineering, Faculty of life science, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh., Mamun AA; Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Santosh, Tangail- 1902, Bangladesh., Amin MN; Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka-1230, Bangladesh.; Pratyasha Health Biomedical Research Center, Dhaka-1230, Bangladesh., Hossain MA; Department of Biotechnology and Genetic Engineering, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh., Ali MC; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Aktar S; Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi, Bangladesh., Sultana A; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh., Rahim ZB; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh., Mitra S; Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Korea., Dash R; Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Korea.
Jazyk:	angličtina
Zdroj:	Current pharmaceutical design [Curr Pharm Des] 2022; Vol. 28 (19), pp. 1561-1580.
DOI:	10.2174/1381612828666220601153426
Abstrakt:	Prostate cancer remains one of the most frequent and deadliest malignancies in males, where the rate of disease progression is closely associated with the type of dietary intake, specifically a Western-style diet. Indeed intake of the Asian diet, which contains abundant phytoestrogens, is inversely correlated with a higher risk of prostate cancer, suggesting a chemoprotective effect of phytoestrogen against cancer progression. Although the role of phytoestrogens in cancer treatment has been well documented, their impact on prostate cancer is not well understood. Therefore, the present review discusses the possible chemopreventive effect of phytoestrogens, emphasizing their efficacy at the different stages of carcinogenesis. Furthermore, phytoestrogens provide a cytoprotective effect in conventional chemotherapy and enhance chemosensitivity to tumor cells, which have also been discussed. This compilation provides a solid basis for future research on phytoestrogens as a promising avenue for anticancer drug development and also recommends these beneficiary compounds in the daily diet to manage and prevent prostate cancer. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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