Synthetic Polymer with a Structure-Driven Hepatic Deposition and Curative Pharmacological Activity in Hepatic Cells.

Autor:	Riber CF; Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus 8000, Denmark., Andersen AHF; Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus 8000, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus 8200, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus 8200, Denmark., Rolskov LA; Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus 8000, Denmark., Zuwala K; Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus 8000, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus 8200, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus 8200, Denmark., Gajda P; Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus 8000, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus 8200, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus 8200, Denmark., Løvschall KB; Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus 8000, Denmark., Dagnæs-Hansen F; Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark., Banda DH; Institute of Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Medical School Hannover/Helmholtz Centre for Infection Research, Hannover, Germany., Pietschmann T; Institute of Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Medical School Hannover/Helmholtz Centre for Infection Research, Hannover, Germany., Tolstrup M; Department of Infectious Diseases, Aarhus University Hospital, Aarhus 8200, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus 8200, Denmark., Zelikin AN; Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus 8000, Denmark.
Jazyk:	angličtina
Zdroj:	ACS macro letters [ACS Macro Lett] 2017 Sep 19; Vol. 6 (9), pp. 935-940. Date of Electronic Publication: 2017 Aug 15.
DOI:	10.1021/acsmacrolett.7b00471
Abstrakt:	Synthetic polymers make strong contributions as tools for delivery of biological drugs and chemotherapeutics. The most praised characteristic of polymers in these applications is complete lack of pharmacological function such as to minimize the side effects within the human body. In contrast, synthetic polymers with curative pharmacological activity are truly rare. Moreover, such activity is typically nonspecific rather than structure-defined. In this work, we present the discovery of poly(ethylacrylic acid) (PEAA) as a polymer with a suit of structure-defined, unexpected, pharmacological, and pharmacokinetic properties not observed in close structural analogues. Specifically, PEAA reveals capacity to bind to albumin with ensuing natural hepatic deposition in vivo and exhibits concurrent inhibitory activity against the hepatitis C virus and inflammation in hepatic cells. Our findings provide a view on synthetic polymers as curative, functional agents and present PEAA as a unique biomedical tool with applications related to health of the human liver.
Databáze:	MEDLINE
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