Using Host-Guest Chemistry to Tune the Kinetics of Morphological Transitions Undertaken by Block Copolymer Vesicles.

Autor: Yao H; School of Science, Northwestern Polytechnical University, Xi'an 710072, P. R. China.; Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, South Yorkshire S3 7HF, U.K., Ning Y; Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, South Yorkshire S3 7HF, U.K., Jesson CP; Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, South Yorkshire S3 7HF, U.K., He J; School of Science, Northwestern Polytechnical University, Xi'an 710072, P. R. China., Deng R; Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, South Yorkshire S3 7HF, U.K., Tian W; School of Science, Northwestern Polytechnical University, Xi'an 710072, P. R. China., Armes SP; Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, South Yorkshire S3 7HF, U.K.
Jazyk: angličtina
Zdroj: ACS macro letters [ACS Macro Lett] 2017 Dec 19; Vol. 6 (12), pp. 1379-1385. Date of Electronic Publication: 2017 Nov 30.
DOI: 10.1021/acsmacrolett.7b00836
Abstrakt: Host-guest chemistry is exploited to tune the rate at which block copolymer vesicles undergo morphological transitions. More specifically, a concentrated aqueous dispersion of poly(glycerol monomethacrylate- co -glycidyl methacrylate)-poly(2-hydroxypropyl methacrylate) [P(GMA- co -GlyMA)-PHPMA] diblock copolymer vesicles was prepared via polymerization-induced self-assembly (PISA). The epoxy groups in the GlyMA residues were ring-opened using a primary amine-functionalized β-cyclodextrin (NH 2 -β-CD) in order to prepare β-CD-decorated vesicles. Addition of azobenzene-methoxypoly(ethylene glycol) (azo-mPEG) to such vesicles results in specific binding of this water-soluble macromolecular reagent to the β-CD groups on the hydrophilic P(GMA- co -GlyMA) stabilizer chains. Such host-guest chemistry induces a morphological transition from vesicles to worms and/or spheres. Furthermore, the rate of this morphological transition can be tuned by UV/visible-light irradiation and/or guest molecule competition. This novel molecular recognition strategy offers considerable scope for the design of new stimulus-responsive diblock copolymer vesicles for targeted delivery and controlled release of cargoes.
Databáze: MEDLINE
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