LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis.

Autor: Polkoff KM; Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA.; North Carolina State University Comparative Medicine Institute, Raleigh, NC, USA., Gupta NK; Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA.; North Carolina State University Comparative Medicine Institute, Raleigh, NC, USA.; Campbell University School of Osteoplastic Medicine, Lillington, NC, USA., Green AJ; North Carolina State University Comparative Medicine Institute, Raleigh, NC, USA.; Department of Biological Sciences, North Carolina State University College of Sciences, Raleigh, NC, USA., Murphy Y; Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA., Chung J; Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA.; North Carolina State University Comparative Medicine Institute, Raleigh, NC, USA., Gleason KL; Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA., Simpson SG; Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA.; RenOVAte Biosciences, Inc., Reisterstown, MD, USA., Walker DM; Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA.; North Carolina State University Comparative Medicine Institute, Raleigh, NC, USA., Collins B; Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA., Piedrahita JA; Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA. japiedra@ncsu.edu.; North Carolina State University Comparative Medicine Institute, Raleigh, NC, USA. japiedra@ncsu.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jun 01; Vol. 12 (1), pp. 9104. Date of Electronic Publication: 2022 Jun 01.
DOI: 10.1038/s41598-022-13056-w
Abstrakt: Hair follicle stem cells are key for driving growth and homeostasis of the hair follicle niche, have remarkable regenerative capacity throughout hair cycling, and display fate plasticity during cutaneous wound healing. Due to the need for a transgenic reporter, essentially all observations related to LGR5-expressing hair follicle stem cells have been generated using transgenic mice, which have significant differences in anatomy and physiology from the human. Using a transgenic pig model, a widely accepted model for human skin and human skin repair, we demonstrate that LGR5 is a marker of hair follicle stem cells across species in homeostasis and development. We also report the strong similarities and important differences in expression patterns, gene expression profiles, and developmental processes between species. This information is important for understanding the fundamental differences and similarities across species, and ultimately improving human hair follicle regeneration, cutaneous wound healing, and skin cancer treatment.
(© 2022. The Author(s).)
Databáze: MEDLINE
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