Investigation of 3D-printed chitosan-xanthan gum patches.

Autor: Altan E; Department of Metallurgy and Materials Engineering, Faculty of Technology, Marmara University, Istanbul, Turkey., Turker N; Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, Turkey., Hindy OA; Department of Biomedical Engineering, School of Engineering and Natural Sciences, Istanbul Medipol University, Istanbul, Turkey., Dirican Z; Eyuboglu College, Istanbul, Turkey., Ozakpinar OB; Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Marmara University, Istanbul, Turkey., Demir AU; Kazlicesme R&D Center and Test Laboratories, Tuzla, Istanbul, Turkey., Kalaskar D; UCL Division of Surgery and Interventional Science, Royal Free Hospital Campus, University College London, Rowland Hill Street, NW3 2PF, UK. Electronic address: d.kalaskar@ucl.ac.uk., Thakur S; Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, B. Krzywoustego 4, 44-100 Gliwice, Poland; School of Advanced Chemical Sciences, Shoolini University, Solan 173229, Himachal Pradesh, India., Gunduz O; Department of Metallurgy and Materials Engineering, Faculty of Technology, Marmara University, Istanbul, Turkey; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey. Electronic address: ucemogu@ucl.ac.uk.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2022 Jul 31; Vol. 213, pp. 259-267. Date of Electronic Publication: 2022 May 29.
DOI: 10.1016/j.ijbiomac.2022.05.158
Abstrakt: In this study, using a new polymer combination of Chitosan(CH)/Xanthan Gum(XG) has been exhibited for wound dressing implementation by the 3D-Printing method, which was fabricated due to its biocompatible, biodegradable, improved mechanical strength, low degradation rate, and hydrophilic nature to develop cell-mimicking, cell adhesion, proliferation, and differentiation. Different concentrations of XG were added to the CH solution as 0.25, 0.50, 0.75, 1, and 2 wt% respectively in the formic acid/distilled water (1.5:8.5) solution and rheologically characterized to evaluate their printability. The results demonstrated that high mechanical strength, hydrophilic properties, and slow degradation rate were observed with the presence and increment of XG concentration within the 3D-Printed patches. Moreover, in vitro cell culture research was conducted by seeding NIH 3T3 fibroblast cells on the patches, proving the cell proliferation rate, viability, and adhesion. Finally, 1% XG and 4% CH containing 3D-Printed patches were great potential for wound dressing applications.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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