| Autor: |
Salerno G; Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.; Laboratory of Clinical Biochemistry, Sant'Andrea University Hospital, Rome, Italy., Gentile G; Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.; Laboratory of Clinical Biochemistry, Sant'Andrea University Hospital, Rome, Italy., De Luca O; Laboratory of Clinical Biochemistry, Sant'Andrea University Hospital, Rome, Italy., Costanzi G; Laboratory of Clinical Biochemistry, Sant'Andrea University Hospital, Rome, Italy., Cirelli G; Occupational Health Department, Sant'Andrea University Hospital, Rome, Italy., Di Simone Di Giuseppe B; Occupational Health Department, Sant'Andrea University Hospital, Rome, Italy., Marcellini L; Occupational Health Department, Sant'Andrea University Hospital, Rome, Italy., Anibaldi P; Hospital Direction and Clinical Departments, Sant'Andrea University Hospital, Rome, Italy., Marcolongo A; Hospital Direction and Clinical Departments, Sant'Andrea University Hospital, Rome, Italy., Simmaco M; Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.; Laboratory of Clinical Biochemistry, Sant'Andrea University Hospital, Rome, Italy., Borro M; Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.; Laboratory of Clinical Biochemistry, Sant'Andrea University Hospital, Rome, Italy. |
| Abstrakt: |
The kinetics of postvaccination serum anti-Spike IgG concentration were determined in 1,541 health care workers (Sant'Andrea Hospital of Rome, Italy) with no prior infection by SARS-COV-2. Anti-Spike IgG were measured at 3, 12, and 24 weeks after the completion of the primary vaccine cycle (two doses of the BNT162b2 vaccine by Biontech/Pfizer) and 3 weeks apart a third BNT162b2 dose. Stratification of the study population by age (decades from 21-30 to 61-70) highlighted that 24 weeks after cycle completion all age groups had an order of magnitude reduction in serum IgG titers. Considering older adults (age 61-70), they had significantly lower serum IgG titers at each time point compared with younger people, except after the booster dose, which induced similar and elevated IgG titers despite the age. |
