Application of exosomes for the alleviation of COVID-19-related pathologies.

Autor: Rezabakhsh A; Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Mahdipour M; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Nourazarian A; Department of Basic Medical Sciences, Khoy University of Medical Sciences, Khoy, Iran., Habibollahi P; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran., Sokullu E; Koç University Research Center for Translational Medicine (KUTTAM), Istanbul, Sariyer, Turkey., Avci ÇB; Department of Medical Biology, Faculty of Medicine, Ege University, Izmir, Turkey., Rahbarghazi R; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Jazyk: angličtina
Zdroj: Cell biochemistry and function [Cell Biochem Funct] 2022 Jul; Vol. 40 (5), pp. 430-438. Date of Electronic Publication: 2022 Jun 01.
DOI: 10.1002/cbf.3720
Abstrakt: The pandemic of COVID-19 caused worldwide concern. Due to the lack of appropriate medications and the inefficiency of commercially available vaccines, lots of efforts are being made to develop de novo therapeutic modalities. Besides this, the possibility of several genetic mutations in the viral genome has led to the generation of resistant strains such as Omicron against neutralizing antibodies and vaccines, leading to worsening public health status. Exosomes (Exo), nanosized vesicles, possess several therapeutic properties that participate in intercellular communication. The discovery and application of Exo in regenerative medicine have paved the way for the alleviation of several pathologies. These nanosized particles act as natural bioshuttles and transfer several biomolecules and anti-inflammatory cytokines. To date, several approaches are available for the administration of Exo into the targeted site inside the body, although the establishment of standard administration routes remains unclear. As severe acute respiratory syndrome coronavirus 2 primarily affects the respiratory system, we here tried to highlight the transplantation of Exo in the alleviation of COVID-19 pathologies.
(© 2022 John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: