The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer.

Autor: Huang C; Urological Department, The Second Xiangya Hospital of Central South University, Changsha, 410011 Hunan, China., Ai X; Urological Department, The First People's Hospital of Pingjiang, Yueyang, 414500 Hunan, China., Hu L; Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, 570208 Hainan, China., Ren D; Urological Department, The Second Xiangya Hospital of Central South University, Changsha, 410011 Hunan, China.
Jazyk: angličtina
Zdroj: Journal of immunology research [J Immunol Res] 2022 May 19; Vol. 2022, pp. 6735310. Date of Electronic Publication: 2022 May 19 (Print Publication: 2022).
DOI: 10.1155/2022/6735310
Abstrakt: Objective: To investigate the value of preoperative urinary nuclear matrix protein 22 (NMP22) and Cystatin B (CSTB) expressions in evaluating the postoperative recurrence of bladder cancer.
Methods: The clinical case data of 102 patients with bladder cancer who underwent surgical treatment from January 2017 to January 2022 were collected, and the patients were divided into a recurrence group ( n = 54) and nonrecurrence group ( n = 48) according to whether the patients recurred after surgery, and the preoperative NMP22 and CSTB expression levels between the two groups were compared. Receiver operating curve (ROC) was used to analyze the evaluation value of preoperative NMP22 and CSTB expression in patients with bladder cancer postoperative recurrence. Logistic multivariate regression method was used to analyze the correlation between preoperative NMP22 and CSTB expression and postoperative bladder cancer recurrence. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of NMP22 and CSTB single detection and combined detection were evaluated for postoperative recurrence of bladder cancer.
Results: The preoperative expression levels of NMP22 and CSTB in the recurrence group were significantly higher than those in the nonrecurrence group ( P < 0.05). The results of ROC curve analysis showed that the AUC of preoperative NMP22 and CSTB expression levels to assess postoperative recurrence of bladder cancer was 0.696 and 0.659, respectively ( P < 0.05). Logistic multivariate regression analysis showed that preoperative NMP22 and CSTB overexpression was an independent risk factor for postoperative recurrence of bladder cancer (OR = 1.042, 2.307, P < 0.05). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of preoperative NMP22 combined with CSTB in evaluating bladder cancer recurrence after surgery were higher than those of preoperative NMP22 and CSTB alone, and the differences were statistically significant ( P < 0.05).
Conclusion: Preoperative NMP22 and CSTB conveying is hardly interrelated to postoperative recurrence of bladder carcinoma and has certain appraisal worth for postoperative recurrence of bladder carcinoma, and the combined testing of the two has a taller appraisal worth. NMP22 combined with CSTB detection will help to detect postoperative recurrence of bladder cancer and formulate effective treatment measures in time.
Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper.
(Copyright © 2022 Changkun Huang et al.)
Databáze: MEDLINE
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