Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets.
| Autor: | Aceil J; Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, The University of Georgia, Athens, GA, United States., Avci FY; Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, The University of Georgia, Athens, GA, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 May 12; Vol. 12, pp. 832254. Date of Electronic Publication: 2022 May 12 (Print Publication: 2022). |
| DOI: | 10.3389/fcimb.2022.832254 |
| Abstrakt: | Streptococcus pneumoniae is an opportunistic pathogen that causes over 1 million deaths annually despite the availability of several multivalent pneumococcal conjugate vaccines (PCVs). Due to the limitations surrounding PCVs along with an evolutionary rise in antibiotic-resistant and unencapsulated strains, conserved immunogenic proteins as vaccine targets continue to be an important field of study for pneumococcal disease prevention. In this review, we provide an overview of multiple classes of conserved surface proteins that have been studied for their contribution to pneumococcal virulence. Furthermore, we discuss the immune responses observed in response to these proteins and their promise as vaccine targets. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Aceil and Avci.) |
| Databáze: | MEDLINE |
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