Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats.

Autor: Dilek M; Department of Pediatrics, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu, Turkey., Kilinc YB; Department of Pediatrics, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu, Turkey., Kilinc E; Department of Physiology, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu, Turkey. Electronic address: erkankilinc@ibu.edu.tr., Torun IE; Department of Physiology, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu, Turkey., Saylan A; Department of Histology and Embryology, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu, Turkey., Duzcu SE; Department of Medical Pathology, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu, Turkey.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2022 Jul 15; Vol. 368, pp. 577894. Date of Electronic Publication: 2022 May 20.
DOI: 10.1016/j.jneuroim.2022.577894
Abstrakt: We investigated effects of activation of TRESK channels by selective activator cloxyquin on excitotoxic-induced brain injury and neuroinflammation involving brain mast cells and inflammatory cytokines in neonatal rats. Three different doses of cloxyquin (0.2, 1 and 5 mg/kg) were studied in ibotenate-induced perinatal brain injury (PBI) in P5 rat-pups. Cerebral lesions and mast cells in coronal brain sections were evaluated. Concentrations of activin A, IL-1β, IL-6 and IL-10 in brain homogenates were measured using ELISA. Cloxyquin dose-dependently exerted protective effects against excitotoxic-induced neonatal brain injury and neuroinflammation. TRESK channels may be a promising new target for the treatment of PBIs.
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Databáze: MEDLINE
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