Quadriceps muscle thickness assessed by ultrasound is independently associated with mortality in hemodialysis patients.
Autor: | Sabatino A; UO Nefrologia, Azienda Ospedaliera- Universitaria Parma, Parma, Italy. alice.sabatino86@gmail.com.; Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy. alice.sabatino86@gmail.com., Kooman JP; Department of Internal Medicine, division of Nephrology University Hospital Maastricht, Maastricht, The Netherlands., Di Motta T; UO Nefrologia, Azienda Ospedaliera- Universitaria Parma, Parma, Italy.; Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy., Cantarelli C; UO Nefrologia, Azienda Ospedaliera- Universitaria Parma, Parma, Italy.; Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy., Gregorini M; SC Nefrologia e Dialisi Azienda USL-IRCCS Reggio Emilia, Reggio Emilia, Italy., Bianchi S; Nephrology and Dialysis Unit, ASL Toscana Nordovest, Italy., Regolisti G; Clinica e Immunologia Medica, Azienda Ospedaliero-Universitaria di Parma e Università degli Studi di Parma, Parma, Italy., Fiaccadori E; UO Nefrologia, Azienda Ospedaliera- Universitaria Parma, Parma, Italy.; Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy. |
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Jazyk: | angličtina |
Zdroj: | European journal of clinical nutrition [Eur J Clin Nutr] 2022 Dec; Vol. 76 (12), pp. 1719-1726. Date of Electronic Publication: 2022 May 31. |
DOI: | 10.1038/s41430-022-01166-7 |
Abstrakt: | Background/objectives: Estimation of muscle mass is an integral part of nutritional assessment in End-Stage Kidney Disease (ESKD) patients on chronic hemodialysis (HD). In this respect, muscle ultrasound (US) is a valid and reliable tool but has not been previously related to outcomes in this population. Aims of this study were to assess the relationship between quadriceps muscle thickness as assessed by US and outcomes in ESKD patients on HD; we also compared US with anthropometry and malnutrition inflammation score (MIS). Subjects/methods: In this prospective study, 181 prevalent patients on HD were included. Thickness of the quadriceps rectus femoris and vastus intermedius (VIT) were assessed separately using ultrasonography, and were indexed for height squared. Mid-arm muscle circumference (MAMC) and area (MAMA) were assessed by anthropometry. MIS was evaluated. In the absence of predetermined cut-offs, values below the median of the distribution of VIT index were considered low. Instead, cut-off for anthropometric values such as MAMC and MAMA were set at ≥90% of agreement with the 50th percentile of the sex- and age-specific normal distribution. Cox-regression analysis was used to assess the association of US, MIS, and anthropometric parameters with mortality. Results: Patients were followed for a median of 35 months. During this period 36% of patients died. Multivariable Cox-regression analysis (adjusted for demographic, biochemical and clinical variables), demonstrated that higher VIT distal index values were independently associated with lower mortality risk (HR: 0.76 (0.59-0.99); P = 0.040), whilst higher MIS values were independently associated with higher (HR 1.22 (1.10-1.35); P < 0.001) mortality risk. When assessing muscle parameters as categorical variables, both low VIT distal index (HR: 1.71 (1.01-2.89); 0.045) and MAMC (HR: 1.74 (1.02-2.96); 0.042) were independently associated with increased risk of death. Conclusion: Indexed distal VIT was independently associated with mortality both as continuous and as a categorical variable. Muscle US is a simple practical tool that adds prognostic information to the bedside nutritional assessment in ESKD patients on maintenance HD. (© 2022. The Author(s), under exclusive licence to Springer Nature Limited.) |
Databáze: | MEDLINE |
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