Clinical profile and outcome of recurrent infective endocarditis.

Autor:	Citro R; Cardiothoracic and Vascular Department, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, Campania, Italy rodolfocitro@gmail.com.; IRCCS Neurological Institute of Southern Italy Neuromed, Pozzilli, Molise, Italy., Chan KL; Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada., Miglioranza MH; Institute of Cardiology, University Foundation of Cardiology, Porto Alegre, Brazil.; Mae de Deus Hospital, Porto Alegre, Brazil.; Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil., Laroche C; EurObservational Research Progamme Department, European Society of Cardiology, Sophia Antipolis, France., Benvenga RM; Cardiothoracic and Vascular Department, University Hospital 'San Giovanni di Dio e Ruggi D'Aragona', Salerno, Campania, Italy., Furnaz S; Department of Research, National Institute of Cardiovascular Diseases, Karachi, Pakistan., Magne J; Department of Cardiology, University Hospital Centre of Limoges, Dupuytren Hospital, Limoges, France.; INSERM 1094, Faculté de Médecine de Limoges, Limoges, France., Olmos C; Instituto Cardiovascular, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdSSC), Madrid, Spain., Paelinck BP; Cardiac Surgery Department, Antwerp University Hospital, Edegem, Belgium., Pasquet A; Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St. Luc Pôle de Recherche Cardiovasculaire (CARD) Institut de Recherche Expérimentale et Clinique (IREC) Université Catholique de Louvain, Brussels, Belgium., Piper C; Clinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Germany., Salsano A; Division of Cardiac Surgery, IRCCS Ospedale Policlinico San Martino, University of Genoa, DISC Department, Genoa, Italy., Savouré A; Cardiology Department, University Hospital of Rouen, Rouen, France., Park SW; Heart Stroke Vascular Institute, Sungkyunkwan University School of Medicine, Samsung Medical Center, Gangnam-Gu, Seoul, The Republic of Korea., Szymański P; Noninvasive Cardiovascular Diagnostic Department, Central Clinical Hospital of the Ministry of Interior and Administration in Warsaw, Poland and Center for Postgraduate Medical Education, Warsaw, Poland., Tattevin P; Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rennes, France., Vallejo Camazon N; Heart Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain., Lancellotti P; Department of Cardiology and Cardiovascular Surgery, University of Liège Hospital, GIGA Cardiovascular Sciences, CHU Sart Tilman, Liège, Belgium.; Gruppo Villa Maria Care and Research, Maria Cecilia Hospital, Cotignola, Ravenna, Italy.; Anthea Hospital, Bari, Italy., Habib G; Service de Cardiologie, Insuffisance Cardiaque et Valvulopathie, Hôpital de la Timone, Marseille, France.
Jazyk:	angličtina
Zdroj:	Heart (British Cardiac Society) [Heart] 2022 Oct 13; Vol. 108 (21), pp. 1729-1736. Date of Electronic Publication: 2022 Oct 13.
DOI:	10.1136/heartjnl-2021-320652
Abstrakt:	Aims: Purpose of this study is to compare the clinical course and outcome of patients with recurrent versus first-episode infective endocarditis (IE). Methods: Patients with recurrent and first-episode IE enrolled in the EUROpean ENDOcarditis (EURO-ENDO) registry including 156 centres were identified and compared using propensity score matching. Recurrent IE was classified as relapse when IE occurred ≤6 months after a previous episode or reinfection when IE occurred >6 months after the prior episode. Results: 3106 patients were enrolled: 2839 (91.4%) patients with first-episode IE (mean age 59.4 (±18.1); 68.3% male) and 267 (8.6%) patients with recurrent IE (mean age 58.1 (±17.7); 74.9% male). Among patients with recurrent IE, 13.2% were intravenous drug users (IVDUs), 66.4% had a repaired or replaced valve with the tricuspid valve being more frequently involved compared with patients with first-episode IE (20.3% vs 14.1%; p=0.012). In patients with a first episode of IE, the aortic valve was more frequently involved (45.6% vs 39.5%; p=0.061). Recurrent relapse and reinfection were 20.6% and 79.4%, respectively. Staphylococcus aureus was the microorganism most frequently observed in both groups (p=0.207). There were no differences in in-hospital and post-hospitalisation mortality between recurrent and first-episode IE. In patients with recurrent IE, in-hospital mortality was higher in IVDU patients. Independent predictors of poorer in-hospital and 1-year outcome, including the occurrence of cardiogenic and septic shock, valvular disease severity and failure to undertake surgery when indicated, were similar for recurrent and first-episode IE. Conclusions: In-hospital and 1-year mortality was similar in patients with recurrent and first-episode IE who shared similar predictors of poor outcome. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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