Traction Bronchiectasis/Bronchiolectasis on CT Scans in Relationship to Clinical Outcomes and Mortality: The COPDGene Study.

Autor: Hata A; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Hino T; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Putman RK; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Yanagawa M; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Hida T; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Menon AA; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Honda O; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Yamada Y; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Nishino M; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Araki T; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Valtchinov VI; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Jinzaki M; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Honda H; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Ishigami K; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Johkoh T; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Tomiyama N; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Christiani DC; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Lynch DA; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., San José Estépar R; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Washko GR; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Cho MH; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Silverman EK; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Hunninghake GM; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.)., Hatabu H; From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).
Jazyk: angličtina
Zdroj: Radiology [Radiology] 2022 Sep; Vol. 304 (3), pp. 694-701. Date of Electronic Publication: 2022 May 31.
DOI: 10.1148/radiol.212584
Abstrakt: Background The clinical impact of interstitial lung abnormalities (ILAs) on poor prognosis has been reported in many studies, but risk stratification in ILA will contribute to clinical practice. Purpose To investigate the association of traction bronchiectasis/bronchiolectasis index (TBI) with mortality and clinical outcomes in individuals with ILA by using the COPDGene cohort. Materials and Methods This study was a secondary analysis of prospectively collected data. Chest CT scans of participants with ILA for traction bronchiectasis/bronchiolectasis were evaluated and outcomes were compared with participants without ILA from the COPDGene study (January 2008 to June 2011). TBI was classified as follows: TBI-0, ILA without traction bronchiectasis/bronchiolectasis; TBI-1, ILA with bronchiolectasis but without bronchiectasis or architectural distortion; TBI-2, ILA with mild to moderate traction bronchiectasis; and TBI-3, ILA with severe traction bronchiectasis and/or honeycombing. Clinical outcomes and overall survival were compared among the TBI groups and the non-ILA group by using multivariable linear regression model and Cox proportional hazards model, respectively. Results Overall, 5295 participants (median age, 59 years; IQR, 52-66 years; 2779 men) were included, and 582 participants with ILA and 4713 participants without ILA were identified. TBI groups were associated with poorer clinical outcomes such as quality of life scores in the multivariable linear regression model (TBI-0: coefficient, 3.2 [95% CI: 0.6, 5.7; P = .01]; TBI-1: coefficient, 3.3 [95% CI: 1.1, 5.6; P = .003]; TBI-2: coefficient, 7.6 [95% CI: 4.0, 11; P < .001]; TBI-3: coefficient, 32 [95% CI: 17, 48; P < .001]). The multivariable Cox model demonstrated that ILA without traction bronchiectasis (TBI-0-1) and with traction bronchiectasis (TBI-2-3) were associated with shorter overall survival (TBI-0-1: hazard ratio [HR], 1.4 [95% CI: 1.0, 1.9; P = .049]; TBI-2-3: HR, 3.8 [95% CI: 2.6, 5.6; P < .001]). Conclusion Traction bronchiectasis/bronchiolectasis was associated with poorer clinical outcomes compared with the group without interstitial lung abnormalities; TBI-2 and 3 were associated with shorter survival. © RSNA, 2022 Online supplemental material is available for this article . See also the editorial by Lee and Im in this issue.
Databáze: MEDLINE