Insular thyroid carcinoma in a young Moroccan man: Case report and review of the literature.

Autor:	Abdellaoui W; Department of Endocrinology-Diabetology-Nutrition, Mohammed VI University Hospital, Medical School, Mohammed the First University, Oujda, Morocco., Assarrar I; Department of Endocrinology-Diabetology-Nutrition, Mohammed VI University Hospital, Medical School, Mohammed the First University, Oujda, Morocco., Benyakhlef S; Department of Endocrinology-Diabetology-Nutrition, Mohammed VI University Hospital, Medical School, Mohammed the First University, Oujda, Morocco., Tahri A; Department of Endocrinology-Diabetology-Nutrition, Mohammed VI University Hospital, Medical School, Mohammed the First University, Oujda, Morocco., Messaoudi N; Department of Endocrinology-Diabetology-Nutrition, Mohammed VI University Hospital, Medical School, Mohammed the First University, Oujda, Morocco., Haloui A; Anathomopathology Laboratory, Mohammed VI University Hospital, Medical School, Mohammed the First University, Oujda, Morocco., Rouf S; Department of Endocrinology-Diabetology-Nutrition, Mohammed VI University Hospital, Medical School, Mohammed the First University, Oujda, Morocco.; Laboratory of Epidemiology, Clinical Research and Public Health, Faculty of Medicine and Pharmacy of Oujda, Mohammed the First University, Morocco., Bennani A; Anathomopathology Laboratory, Mohammed VI University Hospital, Medical School, Mohammed the First University, Oujda, Morocco., Latrech H; Department of Endocrinology-Diabetology-Nutrition, Mohammed VI University Hospital, Medical School, Mohammed the First University, Oujda, Morocco.; Laboratory of Epidemiology, Clinical Research and Public Health, Faculty of Medicine and Pharmacy of Oujda, Mohammed the First University, Morocco.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2022 Apr 06; Vol. 77, pp. 103592. Date of Electronic Publication: 2022 Apr 06 (Print Publication: 2022).
DOI:	10.1016/j.amsu.2022.103592
Abstrakt:	Introduction: Insular thyroid carcinoma (ITC) was defined as a rare malignant thyroid cancer standing in an intermediate position between the well-differentiated (papillary and follicular) and the anaplastic thyroid carcinomas. The incidence was estimated around <1% and 10% worldwide. Despite its rarity, it remains the main cause of death from non-anaplastic follicular cell-derived thyroid cancers. Case Presentation: A 27-year-old single male admitted for a history of a thyroid nodule and intrathoracic extension; with local mass effect, deviating the brachiocephalic trunk to the right. He underwent a total thyroidectomy. Histopathological examination showed a poorly differentiated insular thyroid carcinoma. Radioactive iodine-131 therapy was administred at a dose of 100 mCi, and the patient was maintained on TSH-suppressive therapy. Ultrasensitive Thyroglobulin measurement after thyroxine withdrawal, taken 2 years after radioactive iodine treatment was undetectable as well as thyroid antithyroglobulin antibodies. Conclusion: Our clinical case would enrich the global registry of insular thyroid carcinomas' cases. The main challenge is early detection, aggressive intervention, and close follow-up of affected patients. The advancement in ultra-deep sequencing technologies, will contribute in the development of novel targeted therapies aiming to reduce morbidity and mortality and improve the outcomes in PDTC patients as well. Competing Interests: We have no Competing interests about this scientifical article. (© 2022 The Authors.)
Databáze:	MEDLINE
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