Normal saline injection produces a therapeutic effect in patients with plantar fasciitis: A systematic review and meta-analysis of randomized controlled trials.
Autor: | Peña-Martínez VM; Universidad Autonoma de Nuevo Leon, Orthopedics and Traumatology Service, 'Dr. José Eleuterio González' University Hospital, Monterrey, Mexico., Acosta-Olivo C; Universidad Autonoma de Nuevo Leon, Orthopedics and Traumatology Service, 'Dr. José Eleuterio González' University Hospital, Monterrey, Mexico., Tamez-Mata Y; Universidad Autonoma de Nuevo Leon, Orthopedics and Traumatology Service, 'Dr. José Eleuterio González' University Hospital, Monterrey, Mexico., Simental-Mendía LE; Instituto Mexicano del Seguro Social, Biomedical Research Unit, Delegación Durango, Durango, Mexico., Blázquez-Saldaña J; Universidad Autonoma de Nuevo Leon, Orthopedics and Traumatology Service, 'Dr. José Eleuterio González' University Hospital, Monterrey, Mexico., Vilchez-Cavazos F; Universidad Autonoma de Nuevo Leon, Orthopedics and Traumatology Service, 'Dr. José Eleuterio González' University Hospital, Monterrey, Mexico., Simental-Mendía M; Universidad Autonoma de Nuevo Leon, Orthopedics and Traumatology Service, 'Dr. José Eleuterio González' University Hospital, Monterrey, Mexico. Electronic address: mario.simentalme@uanl.edu.mx. |
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Jazyk: | angličtina |
Zdroj: | Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons [Foot Ankle Surg] 2022 Dec; Vol. 28 (8), pp. 1129-1138. Date of Electronic Publication: 2022 Apr 29. |
DOI: | 10.1016/j.fas.2022.04.005 |
Abstrakt: | Background: Injectable therapies have been increasingly investigated to treat plantar fasciitis in randomized controlled trials (RCT) where normal saline injections are frequently used as placebo. The purpose was to quantify the effect of saline injections and compared against available minimal clinically important difference (MCID) criteria specific for plantar fasciitis to assess if changes were clinically meaningful. Methods: RCT including a placebo group (normal saline) and reporting changes in pain and functional outcomes in plantar fasciitis were identified through a search in MEDLINE, Embase, Web of Science, and Scopus to February 2022. PRISMA guidelines and a registered protocol (PROSPERO: CRD42020214035) were followed to conduct the study. Results: Pooled analysis of 13 RCT (379 subjects) included for analysis revealed a significant improvement on pain (P < .00001) and functional scores (P < .00001) after normal saline injections. These changes exceeded the established MCID criteria. Conclusions: Normal saline injections in plantar fasciitis showed a therapeutic effect with statistically and clinically meaningful improvement when administered in the setting of an RCT for up to 12 months. The control of potential confounders influencing the effect of saline injections is required for future research. (Copyright © 2022 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.) |
Databáze: | MEDLINE |
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