Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor.

Autor:	Muto NA; Centre for Valorization of Amazonian Bioactive Compounds (CVACBA), Federal University of Pará (UFPA), Belém, Brazil., Hamoy M; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences of Federal University of Pará (ICB-UFPA), Belém, Brazil., da Silva Ferreira CB; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences of Federal University of Pará (ICB-UFPA), Belém, Brazil., Hamoy AO; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences of Federal University of Pará (ICB-UFPA), Belém, Brazil., Lucas DCR; Centre for Valorization of Amazonian Bioactive Compounds (CVACBA), Federal University of Pará (UFPA), Belém, Brazil., de Mello VJ; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences of Federal University of Pará (ICB-UFPA), Belém, Brazil., Rogez H; Centre for Valorization of Amazonian Bioactive Compounds (CVACBA), Federal University of Pará (UFPA), Belém, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular neuroscience [Front Cell Neurosci] 2022 May 11; Vol. 16, pp. 872743. Date of Electronic Publication: 2022 May 11 (Print Publication: 2022).
DOI:	10.3389/fncel.2022.872743
Abstrakt:	Epilepsy is one of the most common neurological diseases globally, resulting from a disorder in brain activity. This condition can be triggered by birth trauma, traumatic brain injury (TBI), infections of the brain and stroke. More than 70 million people suffer seizures caused by neurological abnormalities. Approximately 80% of all epileptic patients reside in low-income conditions or in developing countries, and over 75% of patients do not receive proper treatment. Our previous study found an anticonvulsant property of an extract of Euterpe oleracea stone (EEOS) that caused myorelaxation, sedation, and cardiac and respiratory depression after intraperitoneal administration. The present study investigated through electroencephalographic (EEG) profiling the anticonvulsant protective properties of EEOS in induced convulsing rats. Male Wistar rats were treated with EEOS (300 mg/kg), diazepam (DZP) (5 mg/kg), pentylenetetrazol (PTZ) (60 mg/kg) and flumazenil (FMZ) (0.1 mg/kg) by intraperitoneal (i.p.). Electrodes implanted on the dura mater provided EEG data in which EEOS suppressed seizure deflagration caused by PTZ. In addition, EEOS presented no significant difference in comparison to DZP, which has the same mechanism of action. After FMZ injection, a GABAA receptor antagonist blocked the anticonvulsive effect in both the DZP and EEOS groups, suggesting that EEOS exerts it action on the GABAA receptor at the benzodiazepine (BDZ) subunit. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Muto, Hamoy, da Silva Ferreira, Hamoy, Lucas, de Mello and Rogez.)
Databáze:	MEDLINE
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