Post COVID-19 Condition in Children and Adolescents: An Emerging Problem.

Autor:	Izquierdo-Pujol J; IrsiCaixa AIDS Research Institute, Badalona, Spain., Moron-Lopez S; IrsiCaixa AIDS Research Institute, Badalona, Spain.; CIBER de Enfermedades Infecciosas, Madrid, Spain., Dalmau J; IrsiCaixa AIDS Research Institute, Badalona, Spain., Gonzalez-Aumatell A; Department of Pediatrics, Germans Trias i Pujol University Hospital, Autonomous University of Barcelona, Badalona, Spain., Carreras-Abad C; Department of Pediatrics, Germans Trias i Pujol University Hospital, Autonomous University of Barcelona, Badalona, Spain., Mendez M; Department of Pediatrics, Germans Trias i Pujol University Hospital, Autonomous University of Barcelona, Badalona, Spain., Rodrigo C; Department of Pediatrics, Germans Trias i Pujol University Hospital, Autonomous University of Barcelona, Badalona, Spain., Martinez-Picado J; IrsiCaixa AIDS Research Institute, Badalona, Spain.; CIBER de Enfermedades Infecciosas, Madrid, Spain.; Department of Infectious Disease and Immunity, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2022 May 11; Vol. 10, pp. 894204. Date of Electronic Publication: 2022 May 11 (Print Publication: 2022).
DOI:	10.3389/fped.2022.894204
Abstrakt:	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection became a pandemic in 2020 and by March 2022 had caused more than 479 million infections and 6 million deaths worldwide. Several acute and long-term symptoms have been reported in infected adults, but it remains unclear whether children/adolescents also experience persistent sequelae. Hence, we conducted a review of symptoms and pathophysiology associated with post-coronavirus disease 2019 (post-COVID-19) condition in children and adolescents. We reviewed the scientific literature for reports on persistent COVID-19 symptoms after SARS-CoV-2 infection in both children/adolescents and adults from 1 January 2020 to 31 March 2022 (based on their originality and relevance to the broad scope of this review, 26 reports were included, 8 focused on adults and 18 on children/adolescents). Persistent sequelae of COVID-19 are less common in children/adolescents than in adults, possibly owing to a lower frequency of SARS-CoV-2 infection and to the lower impact of the infection itself in this age group. However, cumulative evidence has shown prolonged COVID-19 to be a clinical entity, with few pathophysiological associations at present. The most common post-COVID-19 symptoms in children/adolescents are fatigue, lack of concentration, and muscle pain. In addition, we found evidence of pathophysiology associated with fatigue and/or headache, persistent loss of smell and cough, and neurological and/or cardiovascular symptoms. This review highlights the importance of unraveling why SARS-CoV-2 infection may cause post-COVID-19 condition and how persistent symptoms might affect the physical, social, and psychological well-being of young people in the future. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Izquierdo-Pujol, Moron-Lopez, Dalmau, Gonzalez-Aumatell, Carreras-Abad, Mendez, Rodrigo and Martinez-Picado.)
Databáze:	MEDLINE
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