Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures.

Autor: Demarchi LHF; Laboratório Central de Saúde Pública de Mato Grosso do Sul/SES/MS, Campo Grande 79080-320, Brazil., Bandeira LM; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil., Taira DL; Laboratório Central de Saúde Pública de Mato Grosso do Sul/SES/MS, Campo Grande 79080-320, Brazil., Zardin MCSU; Laboratório Central de Saúde Pública de Mato Grosso do Sul/SES/MS, Campo Grande 79080-320, Brazil., Ibanhes ML; Laboratório Central de Saúde Pública de Mato Grosso do Sul/SES/MS, Campo Grande 79080-320, Brazil., Esposito AOP; Laboratório Central de Saúde Pública de Mato Grosso do Sul/SES/MS, Campo Grande 79080-320, Brazil., De Arruda LDC; Secretaria de Estado de Saúde de Mato Grosso do Sul, Campo Grande 79031-350, Brazil., Gonçalves CCM; Secretaria de Estado de Saúde de Mato Grosso do Sul, Campo Grande 79031-350, Brazil., Weis-Torres SMDS; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil., Cesar GA; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil., Da Cunha RV; Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil., Tanaka TSO; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil., Puga MAM; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil., De Rezende GR; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil., Lopes RB; Secretaria Nacional de Vigilância em Saúde SVS, Ministério da Saúde, Brasília, Distrito Federal 70740-610, Brazil., Uehara SNO; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil., Pinho JRR; Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, Brazil., Carrilho FJ; Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, Brazil., Gomes-Gouvêa MS; Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, Brazil., Motta-Castro ARC; Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.; Fiocruz Mato Grosso do Sul, Fundação Oswaldo Cruz, Campo Grande 79081-746, Brazil.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2022 May 18; Vol. 14 (5). Date of Electronic Publication: 2022 May 18.
DOI: 10.3390/v14051085
Abstrakt: This cross-sectional study aimed to investigate the prevalence and risk factors of Hepatitis B virus infection among Japanese immigrants and their descendants from São Paulo (SP), and to verify the occurrence of occult hepatitis B and coinfection with HCV, Delta, and HTLV. All samples ( n = 2.127) were tested for HBV serological markers by electrochemiluminescence. HBsAg and/or total anti-HBc positive samples were tested for HBV DNA by real-time PCR, and genotyped by sequencing using the Sanger methodology. The prevalence rate of HBV exposure was 13.4% (CI 95%: 11.9-14.9%), and 22 (1.1%) were HBsAg positive. A high rate of susceptibility to HBV infection was found (67.4%; CI 95%: 65.4-69.4%). In contrast, only 19.2% (CI 95%: 17.6-20.9%) presented a serological profile analogous to that elicited by Hepatitis B vaccination. HBV isolates ( n = 8) were classified as genotypes HBV/B1 (62.5%), HBV/C2 (12.5%), HBV/F1b (12.5%), and HBV/A1 (12.5%). Hepatitis B vaccination strategies and educational measures to control this infection should be considered.
Databáze: MEDLINE
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