| Autor: |
Nwe KM; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.; Department of Medical Research, Yangon 11191, Myanmar.; Department of Pathology, North Okkalapa General and Teaching Hospital, Yangon 11031, Myanmar., Ngwe Tun MM; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan., Myat TW; Department of Medical Research, Yangon 11191, Myanmar., Sheng Ng CF; Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.; School of International Health, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan., Htun MM; Department of Medical Research, Yangon 11191, Myanmar., Lin H; Department of Medical Research, Yangon 11191, Myanmar., Hom NS; Department of Medical Research, Yangon 11191, Myanmar., Soe AM; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.; Department of Medical Research, Yangon 11191, Myanmar., Elong Ngono A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Hamano S; Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.; Department of Parasitology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan., Morita K; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan., Thant KZ; Department of Medical Research, Yangon 11191, Myanmar., Shresta S; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Thu HM; Department of Medical Research, Yangon 11191, Myanmar., Moi ML; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.; School of International Health, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan. |
| Abstrakt: |
The dengue virus (DENV) has been endemic in Myanmar since 1970, causing outbreaks every 2-3 years. DENV infection symptoms range from mild fever to lethal hemorrhage. Clinical biomarkers must be identified to facilitate patient risk stratification in the early stages of infection. We analyzed 45 cytokines and other factors in serum samples from the acute phase of DENV infection (within 3-5 days of symptom onset) from 167 patients in Yangon, Myanmar, between 2017 and 2019. All of the patients tested positive for serum DENV nonstructural protein 1 antigen (NS1 Ag); 78.4% and 62.9% were positive for immunoglobulin M (IgM) and G (IgG), respectively; and 18.0%, 19.8%, and 11.9% tested positive for serotypes 1, 3, and 4, respectively. Although the DENV-4 viral load was significantly higher than those of DENV-1 or DENV-3, disease severity was not associated with viral load or serotype. Significant correlations were identified between disease severity and CCL5, SCF, PDGF-BB, IL-10, and TNF-α levels; between NS1 Ag and SCF, CCL5, IFN-α, IL-1α, and IL-22 levels; between thrombocytopenia and IL-2, TNF-α, VEGF-D, and IL-6 levels; and between primary or secondary infection and IL-2, IL-6, IL-31, IL-12p70, and MIP-1β levels. These circulating factors may represent leading signatures in acute DENV infections, reflecting the clinical outcomes in the dengue endemic region, Myanmar. |
