In Vivo Renal Lipid Quantification by Accelerated Magnetic Resonance Spectroscopic Imaging at 3T: Feasibility and Reliability Study.

Autor:	Alhulail AA; Department of Radiology and Medical Imaging, Prince Sattam bin Abdulaziz University, Al-Kharj 16278, Saudi Arabia., Servati M; School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA.; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Ooms N; School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA.; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Akin O; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Dincer A; Department of Radiology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34684, Turkey.; Center for Neuroradiological Applications and Research, Acibadem Mehmet Ali Aydinlar University, Istanbul 34684, Turkey., Thomas MA; Department of Radiology, University of California Los Angeles, Los Angeles, CA 90095, USA., Dydak U; School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA.; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Emir UE; School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA.; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Jazyk:	angličtina
Zdroj:	Metabolites [Metabolites] 2022 Apr 23; Vol. 12 (5). Date of Electronic Publication: 2022 Apr 23.
DOI:	10.3390/metabo12050386
Abstrakt:	A reliable and practical renal-lipid quantification and imaging method is needed. Here, the feasibility of an accelerated MRSI method to map renal fat fractions (FF) at 3T and its repeatability were investigated. A 2D density-weighted concentric-ring-trajectory MRSI was used for accelerating the acquisition of 48 × 48 voxels (each of 0.25 mL spatial resolution) without respiratory navigation implementations. The data were collected over 512 complex-FID timepoints with a 1250 Hz spectral bandwidth. The MRSI sequence was designed with a metabolite-cycling technique for lipid-water separation. The in vivo repeatability performance of the sequence was assessed by conducting a test-reposition-retest study within healthy subjects. The coefficient of variation (CV) in the estimated FF from the test-retest measurements showed a high degree of repeatability of MRSI-FF (CV = 4.3 ± 2.5%). Additionally, the matching level of the spectral signature within the same anatomical region was also investigated, and their intrasubject repeatability was also high, with a small standard deviation (8.1 ± 6.4%). The MRSI acquisition duration was ~3 min only. The proposed MRSI technique can be a reliable technique to quantify and map renal metabolites within a clinically acceptable scan time at 3T that supports the future application of this technique for the non-invasive characterization of heterogeneous renal diseases and tumors.
Databáze:	MEDLINE
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