| Autor: |
Pandrangi SL; Onco-Stem Cell Research Laboratory, Department of Biochemistry and Bioinformatics, GITAM School of Science, GITAM Deemed to Be University, Visakhapatnam 530045, India., Chittineedi P; Onco-Stem Cell Research Laboratory, Department of Biochemistry and Bioinformatics, GITAM School of Science, GITAM Deemed to Be University, Visakhapatnam 530045, India., Chikati R; Department of Biochemistry, Yogivemana University, Kadapa 516005, India., Mosquera JAN; Department of Life Sciences and Agriculture, Armed Forces University-ESPE, Santo Domingo 230101, Ecuador.; Faculty of Industry and Production Sciences, Quevedo State Technical University, km 11/2 via Santo Domingo, Quevedo 120301, Ecuador., Llaguno SNS; Department of Life Sciences and Agriculture, Armed Forces University-ESPE, Santo Domingo 230101, Ecuador., Mohiddin GJ; Department of Life Sciences and Agriculture, Armed Forces University-ESPE, Santo Domingo 230101, Ecuador., Lanka S; Department of Biosciences and Biotechnology, Krishna University, Machilipatnam 521004, India., Chalumuri SS; Onco-Stem Cell Research Laboratory, Department of Biochemistry and Bioinformatics, GITAM School of Science, GITAM Deemed to Be University, Visakhapatnam 530045, India., Maddu N; Department of Biochemistry, Sri Krishnadevaraya University, Anantapur 515003, India. |
| Abstrakt: |
Breast cancer is one of the most common malignancies in women and the leading cause of cancer mortality. Hypercholesterolemia and obesity are potential risk factors for the incidence of breast cancer, and their detection can enhance cancer prevention. In this paper, we discuss the current state of investigations on the importance of lipoproteins, such as low denisity lipoproteins (LDL) and high density lipoproteins (HDL), and cholesterol transporters in the progression of breast cancer, and the therapeutic strategies to reduce breast cancer mortality. Although some research has been unsuccessful at uncovering links between the roles of lipoproteins and breast cancer risk, major scientific trials have found a straight link between LDL levels and incidence of breast cancer, and an inverse link was found between HDL and breast cancer development. Cholesterol and its transporters were shown to have significant importance in the development of breast cancer in studies on breast cancer cell lines and experimental mice models. Instead of cholesterol, 27-hydroxycholesterol, which is a cholesterol metabolite, is thought to promote propagation and metastasis of estrogen receptor-positive breast cancer cell lines. Alteration of lipoproteins via oxidation and HDL glycation are thought to activate many pathways associated with inflammation, thereby promoting cellular proliferation and migration, leading to metastasis while suppressing apoptosis. Medications that lower cholesterol levels and apolipoprotein A-I mimics have appeared to be possible therapeutic agents for preventing excessive cholesterol's role in promoting the development of breast cancer. |
