| Autor: |
Ghamry HI; Department of Home Economics, College of Home Economics, King Khalid University, P.O. Box 960, Abha 61421, Saudi Arabia., Aboushouk AA; Department of Pathology, Faculty of Veterinary Medicine, Alexandria University, Alexandria 22758, Egypt., Soliman MM; Clinical Laboratory Sciences Department, Turabah University College, Taif University, Taif 21995, Saudi Arabia., Albogami SM; Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia., Tohamy HG; Department of Pathology, Faculty of Veterinary Medicine, Alexandria University, Alexandria 22758, Egypt., Okle OSE; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Alexandria University, Alexandria 22758, Egypt., Althobaiti SA; Biology Department, Turabah University College, Taif University, Taif 21995, Saudi Arabia., Rezk S; Department of Histology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt., Farrag F; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt., Helal AI; Department of Histology and Cell Biology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt., Ghoneim HA; Department of Physiology, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22516, Egypt., Shukry M; Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt. |
| Abstrakt: |
This study aims to see if Ginseng ® can reduce the hepatorenal damage caused by malathion. Four groups of forty male Wistar albino rats were alienated. Group 1 was a control group that got orally supplied corn oil (vehicle). Group 2 was intoxicated by malathion dissolved in corn oil orally at 135 mg/kg/day. Group 3 orally received both malathion + Panax Ginseng ® (300 mg/kg/day). Group 4 was orally given Panax Ginseng ® at a 300 mg/kg/day dose. Treatments were administered daily and continued for up to 30 consecutive days. Malathion's toxic effect on both hepatic and renal tissues was revealed by a considerable loss in body weight and biochemically by a marked increase in liver enzymes, LDH, ACP, cholesterol, and functional renal markers with a marked decrease in serum TP, albumin, and TG levels with decreased AchE and Paraoxonase activity. Additionally, malondialdehydes, nitric oxide (nitrite), 8-hydroxy-2-deoxyguanosine, and TNFα with a significant drop in the antioxidant activities were reported in the malathion group. Malathion upregulated the inflammatory cytokines and apoptotic genes, while Nrf2, Bcl2, and HO-1 were downregulated. Ginseng ® and malathion co-treatment reduced malathion's harmful effects by restoring metabolic indicators, enhancing antioxidant pursuit, lowering the inflammatory reaction, and alleviating pathological alterations. So, Ginseng ® may have protective effects against hepatic and renal malathion-induced toxicity on biochemical, antioxidant, molecular, and cell levels. |
